ArticleJournal of bone and mineral metabolism2010
Repetition of continuous PTH treatments followed by periodic withdrawals exerts anabolic effects on rat bone.
Article in Journal of bone and mineral metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Calcitonin: A useful old friend.Journal of musculoskeletal & neuronal interactions · 2020Review
- Effect of PTH and corticotomy on implant movement under mechanical force.BMC oral health · 2020Article
- Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariectomized rats.Bone research · 2017Article
- Runx1 is critical for PTH-induced onset of mesenchymal progenitor cell chondrogenic differentiation.PloS one · 2013Article
- The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization.Journal of tissue engineering and regenerative medicine · 2012Article
- Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials.Materials (Basel, Switzerland) · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various animal experiments and human studies have shown that intermittent injections of parathyroid hormone (PTH) exert anabolic effects on bone, whereas continuous PTH treatment decreases the bone mass and causes hypercalcemia in animals. However, limited data are available with regard to the effects of a repetitive regimen of continuous treatments of PTH followed by periodic withdrawals on the bone metabolism. We investigated the effects of this regimen by comparing the findings of intermittent and continuous PTH treatments in rats. Infusions of PTH for 24 h followed by 6-day withdrawal periods from PTH transiently increased the serum calcium levels on day 1, but these levels were within the normocalcemic range. The repetition of 4 cycles of continuous PTH infusions followed by PTH withdrawals as well as intermittent PTH treatment increased the trabecular bone thickness, osteoblast surface, and bone formation rate. Continuous PTH infusions followed by PTH withdrawals also increased the cortical thickness of the femoral diaphysis and the osteoid volume in trabecular bones, whereas the continuous treatment failed to induce these changes. These findings suggest that continuous PTH treatment followed by PTH withdrawal is a potential regimen that can induce the anabolic effects of PTH in bone metabolism without inducing hypercalcemia.
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