ArticlePediatric nephrology (Berlin, Germany)2010
Improvement of left ventricular mass with antihypertensive therapy in children with hypertension.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Hypertension in Children: Narrative Review of Epidemiology, Outcome and Target Organ Damage.Children (Basel, Switzerland) · 2026Review
- School-based screening for high blood pressure in children and adolescents: a systematic scoping review.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative.Nature reviews. Cardiology · 2026Review
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension.Kidney research and clinical practice · 2025Article
- Pediatric Blood Pressure and Cardiovascular Health in Adulthood.Current hypertension reports · 2024Review
- Association between lifestyle modifications and improvement of early cardiac damage in children and adolescents with excess weight and/or high blood pressure.Pediatric nephrology (Berlin, Germany) · 2023Article
- Reference blood pressure values obtained using the auscultation method for 2-year-old Japanese children: from the Japan Environment and Children's Study.Clinical and experimental nephrology · 2023Article
- Blood Pressure in Children in the 21st Century: What Do We Know and Where Do We Go From Here?Hypertension (Dallas, Tex. : 1979) · 2023Review
- Antihypertensives in Children and Adolescents.Current hypertension reports · 2022Review
- Hypertension and childhood stroke.Pediatric nephrology (Berlin, Germany) · 2021Review
- Two-Year Change in Blood Pressure Status and Left Ventricular Mass Index in Chinese Children.Frontiers in medicine · 2021Article
- Incorporating Risk Stratification Into the Practice of Pediatric Preventive Cardiology.The Canadian journal of cardiology · 2020Review
- Subclinical Organ Damage in Children and Adolescents with Hypertension: Current Guidelines and Beyond.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Review
- Predictors and Consequences of Pediatric Hypertension: Have Advanced Echocardiography and Vascular Testing Arrived?Current hypertension reports · 2019Review
- Ambulatory blood pressure monitoring and neurocognitive function in children with primary hypertension.Pediatric nephrology (Berlin, Germany) · 2018Article
- Why should we screen for arterial hypertension in children and adolescents?Pediatric nephrology (Berlin, Germany) · 2018Review
- Cardiac and Vascular Target Organ Damage in Pediatric Hypertension.Frontiers in pediatrics · 2018Article
- The association between blood pressure and grip strength in adolescents: does body mass index matter?Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Assessment of Left Ventricular Mass and Hypertrophy by Cardiovascular Magnetic Resonance Imaging in Pediatric Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Observational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is paucity of data on the regression of left ventricular hypertrophy (LVH) in hypertensive children. This study assessed the effects of antihypertensive therapy on left ventricular mass in children with and without LVH. Medical records of hypertensive patients who had a baseline and follow-up echocardiogram (echo 1, echo 2) were reviewed. Fifteen of 22 treated patients had LVH at echo 1. Enalapril alone or combined was used in 21/22 cases. Echo 2 was performed at a mean interval of 15 +/- 7 months. The LVH group showed significant decrease in systolic blood pressure z-score (SBPZ) (2.89 +/-1.61 to 1.40 +/- 1.19; p=0.01), diastolic blood pressure z-score (DBPZ) (1.44 +/- 0.90 to 0.26 +/- 0.82; p<0.001), and LV mass index (LVMI) (56.2 +/- 12.50 to 43.7 +/- 8.30; p=0.001), but no significant change in body mass index z-score (BMIZ) (1.79 +/- 0.75 to 1.69 +/- 0.69; p=0.74). In the no-LVH group, SBPZ (3.03 +/- 1.68 to 2.27 +/- 1.81; p=0.356), DBPZ (1.00 +/- 0.87 to 0.63 +/- 0.68; p=0.409), BMIZ (1.08 +/- 0.98 to 1.27 +/- 0.89; p=0.672), and LVMI (29.47 +/- 5.51 to 33.89 +/ -3.06;p=0.374) did not change significantly. Simple linear regression demonstrated that the change in LVMI in the combined group had a significant correlation (r=0.477; p=0.025) with the percentage change in SBPZ. This study demonstrates that LVH in hypertensive children improves with effective blood pressure control.
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