ArticleJournal of neurophysiology2010
NMDAR-dependent control of call duration in Xenopus laevis.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Timescales of call variability in a South American treefrog.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Article
- Generation, Coordination, and Evolution of Neural Circuits for Vocal Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Premotor Neuron Divergence Reflects Vocal Evolution.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Inhibitory and modulatory inputs to the vocal central pattern generator of a teleost fish.The Journal of comparative neurology · 2018Article
- Motor Neurons Tune Premotor Activity in a Vertebrate Central Pattern Generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Evolution of vocal patterns: tuning hindbrain circuits during species divergence.The Journal of experimental biology · 2017Article
- Rhythm generation, coordination, and initiation in the vocal pathways of male African clawed frogs.Journal of neurophysiology · 2017Article
- Probing forebrain to hindbrain circuit functions in Xenopus.Genesis (New York, N.Y. : 2000) · 2017Review
- Harnessing vocal patterns for social communication.Current opinion in neurobiology · 2014Review
- The Xenopus amygdala mediates socially appropriate vocal communication signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Distinct neural and neuromuscular strategies underlie independent evolution of simplified advertisement calls.Proceedings. Biological sciences · 2013Article
- Coding rate and duration of vocalizations of the frog, Xenopus laevis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Shared developmental and evolutionary origins for neural basis of vocal-acoustic and pectoral-gestural signaling.Proceedings of the National Academy of Sciences of the United States of America · 2012Review
- Innovations in motoneuron synchrony drive rapid temporal modulations in vertebrate acoustic signaling.Journal of neurophysiology · 2012Article
- A neuroendocrine basis for the hierarchical control of frog courtship vocalizations.Frontiers in neuroendocrinology · 2011Review
- Vocalization frequency and duration are coded in separate hindbrain nuclei.Nature communications · 2011Article
- Vocal pathway degradation in gonadectomized Xenopus laevis adults.Journal of neurophysiology · 2011Article
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4 authors.
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Abstract
Many rhythmic behaviors, such as locomotion and vocalization, involve temporally dynamic patterns. How does the brain generate temporal complexity? Here, we use the vocal central pattern generator (CPG) of Xenopus laevis to address this question. Isolated brains can elicit fictive vocalizations, allowing us to study the CPG in vitro. The X. laevis advertisement call is temporally modulated; calls consist of rhythmic click trills that alternate between fast (approximately 60 Hz) and slow (approximately 30 Hz) rates. We investigated the role of two CPG nuclei--the laryngeal motor nucleus (n.IX-X) and the dorsal tegmental area of the medulla (DTAM)--in setting rhythm frequency and call durations. We discovered a local field potential wave in DTAM that coincides with fictive fast trills and phasic activity that coincides with fictive clicks. After disrupting n.IX-X connections, the wave persists, whereas phasic activity disappears. Wave duration was temperature dependent and correlated with fictive fast trills. This correlation persisted when wave duration was modified by temperature manipulations. Selectively cooling DTAM, but not n.IX-X, lengthened fictive call and fast trill durations, whereas cooling either nucleus decelerated the fictive click rate. The N-methyl-d-aspartate receptor (NMDAR) antagonist dAPV blocked waves and fictive fast trills, suggesting that the wave controls fast trill activation and, consequently, call duration. We conclude that two functionally distinct CPG circuits exist: 1) a pattern generator in DTAM that determines call duration and 2) a rhythm generator (spanning DTAM and n.IX-X) that determines click rates. The newly identified DTAM pattern generator provides an excellent model for understanding NDMAR-dependent rhythmic circuits.
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