ArticleAmerican journal of epidemiology2010
Intake of polyunsaturated fatty acids and distal large bowel cancer risk in whites and African Americans.
Article in American journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Interaction of Vitamin D Supplements and MarineNutrients · 2024Pooled it
- Omega-3 PUFA intake and the risk of digestive system cancers: A meta-analysis of observational studies.Medicine · 2020Pooled it
- Fish consumption and risk of esophageal cancer and its subtypes: a systematic review and meta-analysis of observational studies.European journal of clinical nutrition · 2013Pooled it
- Fish Intake and Polyunsaturated Fatty Acids in Relation to Colorectal Cancer Risk in the Black Women's Health Study.The Journal of nutrition · 2025Article
- Comparative Effects of Traditional Versus Genetically Modified Soybean Oils on Colon Tumorigenesis in Mice.Foods (Basel, Switzerland) · 2022Article
- ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved.Nutrients · 2020Review
- Updates on Translational Research on Prevention of Polyps and Colorectal Cancer.Clinics in colon and rectal surgery · 2018Review
- Evaluation of the Impact of Cancer Treatment on the Adoption and Consolidation of Pro-Health Attitudes in the Field of Cancer in Treated Patients with Colon Cancer.Journal of cancer education : the official journal of the American Association for Cancer Education · 2018Article
- ω-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice.The Journal of nutritional biochemistry · 2017Article
- Diet, microorganisms and their metabolites, and colon cancer.Nature reviews. Gastroenterology & hepatology · 2016Review
- Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation.Oncotarget · 2016Article
- Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology.Annual review of nutrition · 2016Review
- Insight to drug delivery aspects for colorectal cancer.World journal of gastroenterology · 2016Review
- In vivo regulation of colonic cell proliferation, differentiation, apoptosis, and P27Kip1 by dietary fish oil and butyrate in rats.Cancer prevention research (Philadelphia, Pa.) · 2015Article
- Oxidized derivative of docosahexaenoic acid preferentially inhibit cell proliferation in triple negative over luminal breast cancer cells.In vitro cellular & developmental biology. Animal · 2015Article
- Omega-3 fatty acid is a potential preventive agent for recurrent colon cancer.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer.Prostaglandins & other lipid mediators · 2014Review
- Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer.Progress in lipid research · 2014Review
- Diet and supplements and their impact on colorectal cancer.Journal of gastrointestinal oncology · 2013Review
- Omega-3 polyunsaturated Fatty acids as potential chemopreventive agent for gastrointestinal cancer.Journal of cancer prevention · 2013Review
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5 authors at 1 institution in 1 country.
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Abstract
Long-chain omega-3 polyunsaturated fatty acids (PUFAs) may have antineoplastic properties in the colon. The authors examined the association between intakes of different PUFAs and distal large bowel cancer in a population-based case-control study of 1,503 whites (716 cases; 787 controls) and 369 African Americans (213 cases; 156 controls) in North Carolina (2001-2006). Unconditional logistic regression was used to estimate odds ratios and 95% confidence intervals for distal large bowel cancer risk in relation to quartiles of PUFA intake. Increased consumption of long-chain omega-3 PUFAs was associated with reduced risk of distal large bowel cancer in whites (multivariable odds ratios = 0.88 (95% confidence interval (CI): 0.63, 1.22), 0.69 (95% CI: 0.49, 0.98), and 0.49 (95% CI: 0.34, 0.71) for second, third, and highest vs. lowest quartile) (P(trend) < 0.01). Intake of individual eicosapentaenoic acids and docosahexaenoic acids was inversely related to distal large bowel cancer risk, whereas the ratio of omega-6 to long-chain omega-3 PUFAs was associated with increased risk of distal large bowel cancer in whites, but not among African Americans (P(interaction) < 0.05). Study results support the hypothesis that long-chain omega-3 PUFAs have beneficial effects in colorectal carcinogenesis. Whether or not the possible benefit of long-chain omega-3 PUFAs varies by race warrants further evaluation.
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