ArticleJournal of cell science2010
APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint.Cell reports · 2018Article
- APC/CG3 (Bethesda, Md.) · 2017Article
- Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).Open biology · 2017Review
- Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.Journal of molecular biology · 2015Article
- Deducing protein function by forensic integrative cell biology.PLoS biology · 2013Article
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- APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.Nature structural & molecular biology · 2012Article
- Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint.Chromosoma · 2012Review
- Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation.The Journal of cell biology · 2012Article
- SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2.Cell division · 2012Article
- Structural insights into anaphase-promoting complex function and mechanism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Uncovering ubiquitin and ubiquitin-like signaling networks.Chemical reviews · 2011Review
- emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.Genetics · 2011Article
- Jagesh Shah: a quantitative approach to cell biology. Interview by Caitlin Sedwick.The Journal of cell biology · 2011Article
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- The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis.Frontiers in oncology · 2011Article
- Article
- Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions.The Journal of cell biology · 2010Article
Corrections and comments
- Erratum issued
- Erratum issuedvan der Voet, Moniek [corrected to van der Voet, Monique]
Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
Error-free chromosome segregation depends on timely activation of the multi-subunit E3 ubiquitin ligase APC/C. Activation of the APC/C initiates chromosome segregation and mitotic exit by targeting critical cell-cycle regulators for destruction. The APC/C is the principle target of the mitotic checkpoint, which prevents segregation while chromosomes are unattached to spindle microtubules. We now report the identification and characterization of APC16, a conserved subunit of the APC/C. APC16 was found in association with tandem-affinity-purified mitotic checkpoint complex protein complexes. APC16 is a bona fide subunit of human APC/C: it is present in APC/C complexes throughout the cell cycle, the phenotype of APC16-depleted cells copies depletion of other APC/C subunits, and APC16 is important for APC/C activity towards mitotic substrates. APC16 sequence homologues can be identified in metazoans, but not fungi, by four conserved primary sequence stretches. We provide evidence that the C. elegans gene K10D2.4 and the D. rerio gene zgc:110659 are functional equivalents of human APC16. Our findings show that APC/C is composed of previously undescribed subunits, and raise the question of why metazoan APC/C is molecularly different from unicellular APC/C.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.