Evidence map›Paper›PMID 20392622›Full record

ArticleCurrent opinion in cell biology2010

Nucleolar dominance and ribosomal RNA gene silencing.

Sarah Tucker, Alexa Vitins, Craig S Pikaard

Abstract read
In one paragraph

Article in Current opinion in cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 116 citations in OpenAlex.

  1. Dynamic evolution and hierarchical regulation of rDNA in polyploid oat.The Plant journal : for cell and molecular biology · 2026
    Article
  2. Regulation of nucleolar dominance through allopolyploidization of hexaploid wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
    Article
  3. Review
  4. Review
  5. Transcriptional Silencing of 35S rDNA inInternational journal of molecular sciences · 2024
    Article
  6. Genome Variability in Artificial Allopolyploid Hybrids ofInternational journal of molecular sciences · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Uniparental expression of ribosomal RNA in ×Frontiers in plant science · 2023
    Article
  14. Article
  15. International journal of molecular sciences · 2022
    Review
  16. Article
  17. 5S Ribosomal DNA of GenusFrontiers in plant science · 2022
    Article
  18. Review
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sarah TuckerDepartment of Biology, Washington University, St. Louis, MO 63130, USA.
Alexa Vitins
Craig S Pikaard
Washington University in St. Louis · US

Funding

MOLECULAR GENETICS OF NUCLEOLAR DOMINANCER01GM060380 · NIGMS · WASHINGTON UNIVERSITY · PI PIKAARD, CRAIG STUART · 2000 to 2012
$3.3M
NIGMS NIH HHS GM60380NIGMS NIH HHS R01 GM060380
6 · The paper itself

Abstract

Nucleolar dominance is an epigenetic phenomenon that occurs in genetic hybrids and describes the expression of 45S rRNA genes inherited from one progenitor due to the silencing of the other progenitor's rRNA genes. Nucleolar dominance is a manifestation of rRNA gene dosage control, which also occurs in non-hybrids, regulating the number of active rRNA genes according to the cellular demand for ribosomes and protein synthesis. Ribosomal RNA gene silencing involves changes in DNA methylation and histone modifications, but the molecular basis for choosing which genes to silence remains unclear. Recent studies indicate a role for short interfering RNAs (siRNAs) or structured regulatory RNAs in rRNA gene silencing in plants or mammals, respectively, suggesting that RNA may impart specificity to the choice mechanism.

Indexed as

Gene SilencingAnimalsCell NucleolusChromatinGene DosageGenes, rRNAHumansPlantsRNA, RibosomalChromatinRNA, Ribosomal

Identifiers

PMID20392622
PMCPMC2912983
OpenAlexW2064782430

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.