ArticleThe Journal of allergy and clinical immunology2010
Breast-feeding, aeroallergen sensitization, and environmental exposures during infancy are determinants of childhood allergic rhinitis.
Article in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review.The American journal of clinical nutrition · 2019Pooled it
- Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis.PLoS medicine · 2014Pooled it
- Can Breastfeeding Prevent Long-Term Overweight and Obesity in Children? A Population-Based Cohort Study.Nutrients · 2024Article
- New progress in pediatric allergic rhinitis.Frontiers in immunology · 2024Review
- The Effect of Breastfeeding on Food Allergies in Newborns and Infants.Children (Basel, Switzerland) · 2023Review
- Association between prenatal or postpartum exposure to tobacco smoking and allergic rhinitis in the offspring: An updated meta-analysis of nine cohort studies.Tobacco induced diseases · 2022Article
- International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients with AR: Current knowledge and future strategies.The World Allergy Organization journal · 2020Article
- Early Life Risk Factors in Pediatric EoE: Could We Prevent This Modern Disease?Frontiers in pediatrics · 2020Review
- MicroRNA-466a-3p attenuates allergic nasal inflammation in mice by targeting GATA3.Clinical and experimental immunology · 2019Article
- Early-Life Environmental Factors Can Increase the Risk of Allergic Rhinitis.Clinical and experimental otorhinolaryngology · 2019Article
- Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study).Clinical and experimental otorhinolaryngology · 2019Article
- Using high-resolution residential greenspace measures in an urban environment to assess risks of allergy outcomes in children.The Science of the total environment · 2019Article
- Effect of Residential Greenness and Nearby Parks on Respiratory and Allergic Diseases among Middle School Adolescents in a Chinese City.International journal of environmental research and public health · 2019Article
- Early Intervention is Important to Prevent Sensitization to New Allergens.Medical sciences (Basel, Switzerland) · 2018Review
- International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.International forum of allergy & rhinology · 2018Article
- Reference Values and Utility of Serum Total Immunoglobulin E for Predicting Atopy and Allergic Diseases in Korean Schoolchildren.Journal of Korean medical science · 2017Article
- Pediatric rhinitis risk factors.Experimental and therapeutic medicine · 2016Article
- Allergic Diseases and Internalizing Behaviors in Early Childhood.Pediatrics · 2016Article
- Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics.The World Allergy Organization journal · 2016Review
- Environmental and infectious factors in eosinophilic esophagitis.Best practice & research. Clinical gastroenterology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInfant predictors of early childhood allergic rhinitis (AR) are poorly understood.
objectiveWe sought to identify environmental exposures and host factors during infancy that predict AR at age 3 years.
methodsHigh-risk children from greater Cincinnati were followed annually from ages 1 to 3 years. AR was defined as sneezing, runny, or blocked nose in the prior 12 months and a positive skin prick test (SPT) response to 1 or more aeroallergens. Environmental and standardized medical questionnaires determined exposures and clinical outcomes. Primary activity area dust samples were analyzed for house dust endotoxin (HDE) and (1-3)-beta-D-glucan. Fine particulate matter sampled at 27 monitoring stations was used to estimate personal elemental carbon attributable to traffic exposure by using a land-use regression model.
resultsOf 361 children in this analysis, 116 had AR, and 245 were nonatopic and nonsymptomatic. Prolonged breast-feeding in African American children (adjusted odds ratio [aOR], 0.8; 95% CI, 0.6-0.9) and multiple children in the home during infancy was protective against AR (aOR, 0.4; 95% CI, 0.2-0.8). Food SPT response positivity and tree SPT response positivity in infancy increased the risk of AR at age 3 years (aOR of 4.4 [95% CI, 2.1-9.2] and aOR of 6.8 [95% CI, 2.5-18.7], respectively). HDE exposure was associated with AR; the effect was dependent on exposure level. Elemental carbon attributable to traffic and environmental tobacco smoke exposure showed no effect on AR.
conclusionProlonged breast-feeding in African American subjects and multiple children in the home during infancy reduced the risk of AR at age 3 years. SPT response positivity to food and tree allergens enhanced risk. The HDE effect on AR was related to exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.