ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2010
Differences among sublineages of the East-Asian lineage of Mycobacterium tuberculosis in genotypic clustering.
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis.BMC medicine · 2018Pooled it
- Whole-genome sequencing-based genetic diversity, transmission dynamics, and drug-resistant mutations inFrontiers in public health · 2024Article
- Molecular epidemiology and transmission dynamics of multi-drug resistant tuberculosis strains using whole genome sequencing in the Amhara region, Ethiopia.BMC genomics · 2023Article
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- Extremely lethal and hypervirulentEmerging microbes & infections · 2021Article
- Proteomic analysis of drug-susceptible and multidrug-resistant nonreplicating Beijing strains ofBiochemistry and biophysics reports · 2021Article
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- A Major Mycobacterium tuberculosis outbreak caused by one specific genotype in a low-incidence country: Exploring gene profile virulence explanations.Scientific reports · 2018Article
- Transmissible Mycobacterium tuberculosis Strains Share Genetic Markers and Immune Phenotypes.American journal of respiratory and critical care medicine · 2017Article
- TheFrontiers in immunology · 2017Review
- The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent.PLoS pathogens · 2016Article
- Detection and characterization of drug-resistant conferring genes in Mycobacterium tuberculosis complex strains: A prospective study in two distant regions of Ghana.Tuberculosis (Edinburgh, Scotland) · 2016Article
- Southern East Asian origin and coexpansion of Mycobacterium tuberculosis Beijing family with Han Chinese.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Correlations between drug resistance of Beijing/W lineage clinical isolates of Mycobacterium tuberculosis and sublineages: a 2009-2013 prospective study in Xinjiang province, China.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Article
- There is no correlation between sublineages and drug resistance of Mycobacterium tuberculosis Beijing/W lineage clinical isolates in Xinjiang, China.Epidemiology and infection · 2015Article
- Consequences of genomic diversity in Mycobacterium tuberculosis.Seminars in immunology · 2014Review
- Diversity and evolution of Mycobacterium tuberculosis: moving to whole-genome-based approaches.Cold Spring Harbor perspectives in medicine · 2014Review
- A robust SNP barcode for typing Mycobacterium tuberculosis complex strains.Nature communications · 2014Article
- Mycobacterium tuberculosis strains of the modern sublineage of the Beijing family are more likely to display increased virulence than strains of the ancient sublineage.Journal of clinical microbiology · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
settingThe East-Asian lineage of Mycobacterium tuberculosis is composed of five sublineages, and includes the strains from the Beijing spoligotype family. In some studies these strains were highly pathogenic, although other studies did not support this finding.
objectiveTo determine if the sublineages of the East-Asian lineage of M. tuberculosis differ in their capacity to cause secondary cases, as assessed by genotypic clustering of isolates.
designIn a population-based study of 545 patients with M. tuberculosis from the East-Asian lineage in San Francisco, we used DNA-based fingerprinting to identify genotypic clustering, which was compared among the different sublineages defined by large sequence polymorphism.
resultsStrains from sublineage 207 had the highest frequency of genotypic clustering. In the multivariate analysis, only patients born in the United States were associated with clustering.
conclusionsWe found evidence in a univariate analysis that the different East-Asian sublineages of M. tuberculosis have different frequencies of genotypic clustering. The effect size for this difference was unchanged in multivariate analysis, although loss of observations due to missing data resulted in a non-significant P value. It is tantalizing to hypothesize that the different East-Asian sublineages may differ in their capacity to cause secondary cases.
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20392345PMC3625672What OpenQuestion holds
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