ArticleAnnals of the New York Academy of Sciences2010
Nocturnin: a circadian target of Pparg-induced adipogenesis.
Article in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling.Journal of periodontal research · 2026Review
- Bone marrow adipocytes: key players in vascular niches, aging, and disease.Frontiers in cell and developmental biology · 2025Review
- Mini review: Bidirectional Regulation of Circadian Rhythm by Suprachiasmatic Nucleus and Nuclear Receptors in Female Mammals.Journal of circadian rhythms · 2025Review
- Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice.Nature communications · 2024Article
- 9-HODE and 9-HOTrE alter mitochondrial metabolism, increase triglycerides, and perturb fatty acid uptake and synthesis associated gene expression in HepG2 cells.Prostaglandins, leukotrienes, and essential fatty acids · 2024Article
- Review
- Voltage-gated sodium channelProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Angiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.Molecular metabolism · 2022Article
- The cause-effect relationship between bone loss and Alzheimer's disease using statistical modeling.Medical hypotheses · 2019Observational
- Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice.BMC genomics · 2018Article
- Article
- The hepatic transcriptome of young suckling and aging intrauterine growth restricted male rats.Journal of cellular biochemistry · 2015Article
- Nuclear receptors rock around the clock.EMBO reports · 2014Review
- Nocturnin: at the crossroads of clocks and metabolism.Trends in endocrinology and metabolism: TEM · 2012Review
- Chronobiological Effects on Obesity.Current obesity reports · 2012Article
- Article
- An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis.Annals of the New York Academy of Sciences · 2011Article
- PPARγ: a circadian transcription factor in adipogenesis and osteogenesis.Nature reviews. Endocrinology · 2010Review
- Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA.Endocrinology · 2010Article
- Skeletal aging and the adipocyte program: New insights from an "old" molecule.Cell cycle (Georgetown, Tex.) · 2010Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Nuclear receptors (NRs) control cell fate and regulate tissue function. Some of the NRs are expressed in a circadian and tissue-specific manner. Clock genes are part of the circadian network and fine-tune gene expression in adipose and skeletal tissues. Pparg, a master transcription factor that determines adipogenesis, exhibits a circadian expression pattern in white adipose tissue and liver. Here we report the finding that the message and protein for a peripheral clock gene, nocturnin, is markedly upregulated with Pparg activation in adipocytes and bone marrow stromal cells. Nocturnin is also expressed in relatively high amounts in other tissues that may have physiologic relevance for bone, including the brain and hypothalamus. Of importance, we found polymorphic strain differences in bone marrow nocturnin expression that relate to phenotypic determinants of skeletal acquisition. Defining the function of nocturnin in peripheral tissues should provide new insights into lineage allocation and the intimate relationship between nuclear receptors and physiologic timekeeping.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.