ArticleChemistry (Weinheim an der Bergstrasse, Germany)2010
A spirocyclohexyl nitroxide amino acid spin label for pulsed EPR spectroscopy distance measurements.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 75 citations in OpenAlex.
- Sigmatropic rearrangement enables access to a highly stable spirocyclic nitroxide for protein spin labelling.Chemical communications (Cambridge, England) · 2025Article
- Exploring tunneling ESEEM beyond methyl groups in nitroxides at low temperatures.Physical chemistry chemical physics : PCCP · 2024Article
- Cucurbit[7]uril Enhances Distance Measurements of Spin-Labeled Proteins.Journal of the American Chemical Society · 2023Article
- Synthesis and Properties of (1International journal of molecular sciences · 2023Article
- Conformational tuning improves the stability of spirocyclic nitroxides with long paramagnetic relaxation times.Communications chemistry · 2023Article
- Quantifying methyl tunneling induced (de)coherence of nitroxides in glassyPhysical chemistry chemical physics : PCCP · 2023Article
- Effects of Spiro-Cyclohexane Substitution of Nitroxyl Biradicals on Dynamic Nuclear Polarization.Molecules (Basel, Switzerland) · 2022Article
- Peek Inside the Water Mixtures of Ionic Liquids at Molecular Level: Microscopic Properties Probed by EPR Spectroscopy.International journal of molecular sciences · 2021Article
- Spin-spin interaction and relaxation in two trityl-nitroxide diradicals.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2021Article
- Bis-Spiro-Oxetane and Bis-Spiro-Tetrahydrofuran Pyrroline Nitroxide Radicals: Synthesis and Electron Spin Relaxation Studies.The Journal of organic chemistry · 2021Article
- Validation of Structural Grounds for Anomalous Molecular Mobility in Ionic Liquid Glasses.Molecules (Basel, Switzerland) · 2021Article
- Spirocyclic Nitroxides as Versatile Tools in Modern Natural Sciences: From Synthesis to Applications. Part I. Old and New Synthetic Approaches to Spirocyclic Nitroxyl Radicals.Molecules (Basel, Switzerland) · 2021Review
- Supramolecular Approach to Electron Paramagnetic Resonance Distance Measurement of Spin-Labeled Proteins.The journal of physical chemistry. B · 2020Article
- An x-band continuous wave saturation recovery electron paramagnetic resonance spectrometer based on an arbitrary waveform generator.The Review of scientific instruments · 2019Article
- Unexpected one-pot formation of the 1Beilstein journal of organic chemistry · 2019Article
- Synthesis of Nanometer Sized Bis- and Tris-trityl Model Compounds with Different Extent of Spin-Spin Coupling.Molecules (Basel, Switzerland) · 2018Article
- Azaadamantyl nitroxide spin label: complexation with β-cyclodextrin and electron spin relaxation.Free radical research · 2018Article
- Synthesis and Electron Spin Relaxation of Tetracarboxylate Pyrroline Nitroxides.The Journal of organic chemistry · 2017Article
- Room-temperature distance measurements of immobilized spin-labeled protein by DEER/PELDOR.Biophysical journal · 2015Article
- The spatial effect of protein deuteration on nitroxide spin-label relaxation: implications for EPR distance measurement.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Site-directed spin labeling and EPR spectroscopy offer accurate, sensitive tools for the characterization of structure and function of macromolecules and their assemblies. A new rigid spin label, spirocyclohexyl nitroxide alpha-amino acid and its N-(9-fluorenylmethoxycarbonyl) derivative, have been synthesized, which exhibit slow enough spin-echo dephasing to permit accurate distance measurements by pulsed EPR spectroscopy at temperatures up to 125 K in 1:1 water/glycerol and at higher temperatures in matrices with higher glass transition temperatures. Distance measurements in the liquid nitrogen temperature range are less expensive than those that require liquid helium, which will greatly facilitate applications of pulsed EPR spectroscopy to the study of structure and conformation of peptides and proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.