ArticleCell stress & chaperones2010
Hsp60 and Hsp10 increase in colon mucosa of Crohn’s disease and ulcerative colitis.
Article in Cell stress & chaperones, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Cellular Stress and Immune Activation in Celiac Disease: Is the Chaperone System a Key Player?Biology · 2026Review
- Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates inMicroorganisms · 2023Article
- Inflammatory Bowel Diseases: An Updated Overview on the Heat Shock Protein Involvement.International journal of molecular sciences · 2023Review
- Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies.International journal of molecular sciences · 2023Article
- Advances of Heat Shock Family in Ulcerative Colitis.Frontiers in pharmacology · 2022Review
- The New Proactive Approach and Precision Medicine in Crohn's Disease.Biomedicines · 2020Review
- HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-Oxidative medicine and cellular longevity · 2020Article
- Biochemical Markers of Colorectal Cancer - Present and Future.Cancer management and research · 2020Review
- Mitochondrial Heat Shock Response Induced by Ectromelia Virus is Accompanied by Reduced Apoptotic Potential in Murine L929 Fibroblasts.Archivum immunologiae et therapiae experimentalis · 2019Article
- Novel serum markers HSP60, CHI3L1, and IGFBP-2 in metastatic colorectal cancer.Oncology letters · 2019Article
- The Functions and Therapeutic Potential of Heat Shock Proteins in Inflammatory Bowel Disease-An Update.International journal of molecular sciences · 2019Review
- Elongated Flexuous Plant Virus-Derived Nanoparticles Functionalized for Autoantibody Detection.Nanomaterials (Basel, Switzerland) · 2019Article
- Hsp60 as a Novel Target in IBD Management: A Prospect.Frontiers in pharmacology · 2019Review
- Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets.World journal of gastroenterology · 2018Review
- Pharmacogenetics in inflammatory bowel disease: understanding treatment response and personalizing therapeutic strategies.Pharmacogenomics and personalized medicine · 2017Review
- Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications.Mucosal immunology · 2016Review
- Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease.World journal of gastroenterology · 2015Review
- Hsp27 and Hsp70 in chronic obstructive pulmonary disease: certainties vs doubts.Cell stress & chaperones · 2015Article
- Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.Cell stress & chaperones · 2014Article
- Hsp10 nuclear localization and changes in lung cells response to cigarette smoke suggest novel roles for this chaperonin.Open biology · 2014Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this work was to determine in colon mucosa of Crohn’s disease (CD) and ulcerative colitis (UC) in relapse: a) the levels of the chaperonins Hsp60 and Hsp10; b) the quantity of inflammatory cells; and c) if the levels of chaperonins parallel those of inflammation cells. Twenty cases of CD and UC and twenty normal controls (NC) were studied using immunohistochemistry, Western blotting and immunofluorescence. Immunohistochemically, Hsp60 and Hsp10 were increased in both inflammatory bowel diseases (IBD) compared to NC. These results were confirmed by Western blotting. Hsp60 and Hsp10 occurred in the cytoplasm of epithelial cells in CD and UC but not in NC. Hsp60 and Hsp10 co-localised to epithelial cells of mucosal glands but not always in connective tissue cells of lamina propria, where only Hsp60 or, less often, Hsp10 was found. Cells typical of inflammation were significantly more abundant in CD and UC than in NC. Since chaperonins are key factors in the activation of the immune system leading to inflammation, we propose that they play a central role in the pathogenesis of the two diseases, which, consequently, ought to be studied as chaperonopathies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.