ArticleSchmerz (Berlin, Germany)2010
[Altered pain thresholds during and after opioid withdrawal in patients with chronic low back pain].
Article in Schmerz (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Alleviation of opioid withdrawal by cannabis and delta-9-tetrahydrocannabinol: A systematic review of observational and experimental human studies.Drug and alcohol dependence · 2022Pooled it
- Canadian guideline for safe and effective use of opioids for chronic noncancer pain: clinical summary for family physicians. Part 1: general population.Canadian family physician Medecin de famille canadien · 2011Guideline
- Changes in peripheral and central sensitization in patients undergoing occipital nerve stimulation.British journal of pain · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOpioids as the strongest pain drugs are often used for chronic pain although their long-term efficacy has not yet been clarified. In this longitudinal study, we compared the pain sensitivity of patients with chronic low back pain (cLBP) under long-term opioid use and treated with multidisciplinary pain therapy.
methodsThe pain sensitivity was measured by the quantitative sensory testing (QST) technique at admission, discharge and 6 months after the beginning of the study in 34 patients with both cLBP and opioid medication, 33 opioid-naive cLBP patients and those neither with pain nor opioid use (HC). Both patient groups underwent a 3-week multidisciplinary pain therapy (MDPT).
resultsUnder opioid use, the patients showed significantly lower cold and heat pain thresholds compared to HC and delayed reaction to warm stimuli. After 3 weeks of MDPT, opioid-positive patients still had a lower pain threshold to cold and heat stimuli, while opioid-naive patients normalised their pain perception.
conclusionOur findings suggest that long-term use of opioids intensifies the peripheral sensitisation of cLBP. The MDPT can counteract this process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.