ArticleThe EMBO journal2010
Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Developmental system drift in the patterning of the arthropod tarsus.Proceedings. Biological sciences · 2026Article
- The ALX4 dimer structure provides insight into how disease alleles impact function.Nature communications · 2025Article
- Experimental approaches to investigate biophysical interactions between homeodomain transcription factors and DNA.Biochimica et biophysica acta. Gene regulatory mechanisms · 2025Review
- Almost 40 years of studying homeobox genes in C. elegans.Development (Cambridge, England) · 2024Article
- Cooperative Gsx2-DNA binding requires DNA bending and a novel Gsx2 homeodomain interface.Nucleic acids research · 2024Article
- A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus (OdsH).G3 (Bethesda, Md.) · 2024Article
- Coevolution of the Tlx homeobox gene with medusa development (Cnidaria: Medusozoa).Communications biology · 2023Article
- Structural and functional analysis of the human cone-rod homeobox transcription factor.Proteins · 2022Article
- Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA.Briefings in bioinformatics · 2022Article
- Structure of the unique tetrameric STENOFOLIA homeodomain bound with target promoter DNA.Acta crystallographica. Section D, Structural biology · 2021Article
- Dynamic Molecular Evolution of Mammalian Homeobox Genes: Duplication, Loss, Divergence and Gene Conversion Sculpt PRD Class Repertoires.Journal of molecular evolution · 2021Article
- Molecular Cloning, Purification and Characterization of Mce1R of Mycobacterium tuberculosis.Molecular biotechnology · 2021Article
- Investigating Developmental and Epileptic Encephalopathy UsingInternational journal of molecular sciences · 2020Review
- Distortion of double-stranded DNA structure by the binding of the restriction DNA glycosylase R.PabI.Nucleic acids research · 2020Article
- Biallelic sequence and structural variants in RAX2 are a novel cause for autosomal recessive inherited retinal disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Phylogenetic and mutational analyses of human LEUTX, a homeobox gene implicated in embryogenesis.Scientific reports · 2018Article
- Structural changes in DNA-binding proteins on complexation.Nucleic acids research · 2018Article
- Tissue-specific enhancer repression through molecular integration of cell signaling inputs.PLoS genetics · 2017Article
- Tetrameric structure of the restriction DNA glycosylase R.PabI in complex with nonspecific double-stranded DNA.Scientific reports · 2016Article
- A Novel Approach to Predict Core Residues on Cancer-Related DNA-Binding Domains.Cancer informatics · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To achieve accurate gene regulation, some homeodomain proteins bind cooperatively to DNA to increase those site specificities. We report a ternary complex structure containing two homeodomain proteins, aristaless (Al) and clawless (Cll), bound to DNA. Our results show that the extended conserved sequences of the Cll homeodomain are indispensable to cooperative DNA binding. In the Al-Cll-DNA complex structure, the residues in the extended regions are used not only for the intermolecular contacts between the two homeodomain proteins but also for the sequence-recognition mechanism of DNA by direct interactions. The residues in the extended N-terminal arm lie within the minor groove of DNA to form direct interactions with bases, whereas the extended conserved region of the C-terminus of the homeodomain interacts with Al to stabilize and localize the third alpha helix of the Cll homeodomain. This structure suggests a novel mode for the cooperativity of homeodomain proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.