ArticleJournal of lipid research2010
Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Candidate SNP Markers Significantly Altering the Affinity of the TATA-Binding Protein for the Promoters of Human Genes Associated with Primary Open-Angle Glaucoma.International journal of molecular sciences · 2024Article
- Roles of lipid droplets and related proteins in metabolic diseases.Lipids in health and disease · 2024Review
- Review
- Perilipins at a glance.Journal of cell science · 2022Article
- Role of caveolin-1 in hepatocellular carcinoma arising from non-alcoholic fatty liver disease.Cancer science · 2018Article
- Hepatic caveolin-1 is enhanced inFEBS open bio · 2016Article
- CD36 binds oxidized low density lipoprotein (LDL) in a mechanism dependent upon fatty acid binding.The Journal of biological chemistry · 2015Article
- Pleiotropic effects of cavin-1 deficiency on lipid metabolism.The Journal of biological chemistry · 2014Article
- Intestinal caveolin-1 is important for dietary fatty acid absorption.Biochimica et biophysica acta · 2013Article
- Caveolae as plasma membrane sensors, protectors and organizers.Nature reviews. Molecular cell biology · 2013Review
- Reprogramming neutral lipid metabolism in mouse dendritic leucocytes hosting live Leishmania amazonensis amastigotes.PLoS neglected tropical diseases · 2013Article
- Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes.Trends in endocrinology and metabolism: TEM · 2011Review
- Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity.Journal of lipid research · 2011Article
- Review
- Cholesterol asymmetry in synaptic plasma membranes.Journal of neurochemistry · 2011Article
- Caveolae and lipid trafficking in adipocytes.Clinical lipidology · 2011Article
- The role of proline in the membrane re-entrant helix of caveolin-1.The Journal of biological chemistry · 2010Article
- Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Ectopic expression of caveolin-1 in HEK293 cells enhances FA sequestration in membranes as measured by a pH-sensitive fluorescent dye (1). We hypothesized that sequestration of FA is due to the enrichment of caveolin in the cytosolic leaflet and its ability to facilitate the formation of lipid rafts to buffer high FA levels. Here we show that ec-topic expression of caveolin-3 also results in enhanced FA sequestration. To further discriminate the effect that caveolins have on transmembrane FA movement and distribution, we labeled the outer membrane leaflet with fluorescein-phosphatidylethanolamine (FPE), whose emission is quenched by the presence of FA anions. Real-time measurements made with FPE and control experiments with positively charged fatty amines support our hypothesis that caveolins promote localization of FA anions through interactions with basic amino acid residues (lysines and arginines) present at the C termini of caveolins-1 and -3.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.