ArticleThe Annals of pharmacotherapy2010
Refill adherence to oral hypoglycemic agents and glycemic control in veterans.
Article in The Annals of pharmacotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Adherence to and persistence with antidiabetic medications and associations with clinical and economic outcomes in people with type 2 diabetes mellitus: A systematic literature review.Diabetes, obesity & metabolism · 2022Pooled it
- Trial
- Development and feasibility of a text messaging and interactive voice response intervention for low-income, diverse adults with type 2 diabetes mellitus.Journal of diabetes science and technology · 2013Trial
- Impact of Non-Payment of Salaries on Treatment Interruption among Patients with Diabetes.JMA journal · 2025Article
- Impact of Second-Line Combination Treatment for Type 2 Diabetes Mellitus on Disease Control: A Population-Based Cohort Study.Drugs - real world outcomes · 2023Article
- Racial and Regional Disparities in Outcomes Among Veterans Initially Adherent to Oral Antidiabetic Therapies: an Observational Cohort Study.Journal of general internal medicine · 2020Observational
- Article
- Recent metformin adherence and the risk of hypoglycaemia in the year following intensification with a sulfonylurea.Diabetic medicine : a journal of the British Diabetic Association · 2019Article
- Lack of Treatment Persistence and Treatment Nonadherence as Barriers to Glycaemic Control in Patients with Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019Review
- Identifying Risk of Viral Failure in Treated HIV-Infected Patients Using Different Measures of Adherence: The Antiretroviral Therapy Cohort Collaboration.Journal of clinical medicine · 2018Article
- A Class Comparison of Medication Persistence in People with Type 2 Diabetes: A Retrospective Observational Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2018Article
- The Impact of Health Care Appointment Non-Adherence on Graft Outcomes in Kidney Transplantation.American journal of nephrology · 2017Article
- The Office Guidelines Applied to Practice program improves secondary prevention of heart disease in Federally Qualified Healthcare Centers.Preventive medicine reports · 2016Article
- Observational
- Impact of Cardiovascular Risk Factors on Graft Outcome Disparities in Black Kidney Transplant Recipients.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Observational
- Comprehensive Medication Management and Medication Adherence for Chronic Conditions.Journal of managed care & specialty pharmacy · 2016Article
- Disparities in the use of a mHealth medication adherence promotion intervention for low-income adults with type 2 diabetes.Journal of the American Medical Informatics Association : JAMIA · 2016Article
- Adherence to Oral Medications for Hypertension and Diabetes in Veterans with Comorbid Airflow Limitation.Annals of the American Thoracic Society · 2015Article
- Stress, depression and medication nonadherence in diabetes: test of the exacerbating and buffering effects of family support.Journal of behavioral medicine · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough medication nonadherence may contribute to inadequate diabetes control, adherence is not routinely measured. Persistence, the continuous refill of medications, is one metric that could be integrated into clinical care if associated with glycemic control.
objectiveTo characterize the association of persistence levels (non-, good, overpersistence) with hemoglobin A(1c) (A1C) over 1 year in newly medicated diabetics in the Veterans Administration.
methodsEligible veterans were > or =18 years and first filled a prescription for oral hypoglycemic agents (OHA) between January 1, 2000, and December 31, 2002. The date the OHA was first dispensed was defined as the baseline date. Subjects must have filled at least 1 prescription for any drug, but no diabetes medications, during the 12 months preceding the baseline date. Persistence was measured in days supply of medication over 365 days and defined as non- (<0.80), good (> or =0.8-1.10), and over- (>1.10) persistence. The main outcome measure was achieving goal A1C (< or =7.0%) after 1 year.
resultsA total of 56,181 veterans were included. Veterans were male (97%) and white (67%) with comorbid hypertension (58%) and hyperlipidemia (40%). Median age was 63 years, while median baseline A1C was 7.7%. Fifty-two percent of patients had good persistence; 25% were overpersistent. Good persistence was associated with achieving goal A1C (RR 1.07; 95% CI 1.06 to 1.09). The association of overpersistence with the same outcome (RR 0.95; 95% CI 0.94 to 0.97) was lower than good persistence, but higher than nonpersistence (RR 0.93; 95% CI 0.92 to 0.94).
conclusionsGood persistence was associated with glycemic control. Overpersistent patients were common and more likely than nonpersistent patients, but less likely than good persisters to attain goal A1C. Estimating these different strata of persistence may be useful in identifying patients at risk of poor glycemic control.
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