ArticleThe Plant cell2010
VND-INTERACTING2, a NAC domain transcription factor, negatively regulates xylem vessel formation in Arabidopsis.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers.
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177 citing papers in PubMed, 367 citations in OpenAlex.
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- The NAC transcription factor BrrNAC082 positively mediates leaf senescence in Brassica rapa.The Plant journal : for cell and molecular biology · 2026Article
- Regulation of developmental transitions in plants: the role of VIVAPAROUS ABI3-LIKE (VAL) repressors.Journal of plant research · 2026Review
- NUT1-Exo70A1 Regulates Xylem Vessel Development and Influences Water Use Efficiency in Maize.Nature communications · 2026Article
- Comparative analysis of NAC genes and their expression patterns under various treatments in Dendrobium huoshanense.BMC plant biology · 2025Article
- Differentiation Trajectory of Virus-Induced Tumour Cells in Rice Revealed by Single-Cell RNA Sequencing.Plant biotechnology journal · 2025Article
- XND1-centered network regulates salt tolerance by integrating root xylem plasticity and NaProceedings of the National Academy of Sciences of the United States of America · 2025Article
- CmVNI2-CmMYB3 module regulates flavonol biosynthesis in response to low temperature in chrysanthemum flower.Molecular horticulture · 2025Article
- Cloning and Functional Analysis ofPlants (Basel, Switzerland) · 2025Article
- The role of VND transcription factors in xylem vessel development and secondary wall formation.The New phytologist · 2025Review
- Sugarcane microRNA shy-miR164 regulates sugar metabolism through direct cleavage of the transcription factor ScNAC mRNA.Plant physiology · 2025Article
- The Molecular Mechanism and Effects of Root Pruning Treatment on Blueberry Tree Growth.Plants (Basel, Switzerland) · 2025Article
- Isolation and Expression Pattern Analysis ofPlants (Basel, Switzerland) · 2025Article
- IDD10-NAC079 transcription factor complex regulates sheath blight resistance by inhibiting ethylene signaling in rice.Journal of advanced research · 2025Article
- Tomato HAIRY MERISTEM4, expressed in the phloem, is required for proper shoot and fruit development.Horticulture research · 2025Article
- WRKY36-PIL15 Transcription Factor Complex Negatively Regulates Sheath Blight Resistance and Seed Development in Rice.Plants (Basel, Switzerland) · 2025Article
- Article
- Genome-wide identification, transcriptional profiling, and miRNA-binding site analysis of theFrontiers in plant science · 2025Article
- Active protein ubiquitination regulates xylem vessel functionality.The Plant cell · 2024Article
- Article
117 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis thaliana NAC domain transcription factor VASCULAR-RELATED NAC-DOMAIN7 (VND7) acts as a master regulator of xylem vessel differentiation. To understand the mechanism by which VND7 regulates xylem vessel differentiation, we used a yeast two-hybrid system to screen for proteins that interact with VND7 and identified cDNAs encoding two NAC domain proteins, VND-INTERACTING1 (VNI1) and VNI2. Binding assays demonstrated that VNI2 effectively interacts with VND7 and the VND family proteins, VND1-5, as well as with other NAC domain proteins at lower affinity. VNI2 is expressed in both xylem and phloem cells in roots and inflorescence stems. The expression of VNI2 overlaps with that of VND7 in elongating vessel precursors in roots. VNI2 contains a predicted PEST motif and a C-terminally truncated VNI2 protein, which lacks part of the PEST motif, is more stable than full-length VNI2. Transient reporter assays showed that VNI2 is a transcriptional repressor and can repress the expression of vessel-specific genes regulated by VND7. Expression of C-terminally truncated VNI2 under the control of the VND7 promoter inhibited the normal development of xylem vessels in roots and aerial organs. These data suggest that VNI2 regulates xylem cell specification as a transcriptional repressor that interacts with VND proteins and possibly also with other NAC domain proteins.
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