ArticlePhysiological genomics2010
Genetic architecture of voluntary exercise in an advanced intercross line of mice.
Article in Physiological genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Can a Hybrid Line Break a Selection Limit on Behavioral Evolution in Mice?Behavior genetics · 2025Article
- Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice.Cell reports · 2023Article
- Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice.Genetics · 2020Article
- Using the natural variation of mouse populations to understand host-gut microbiome interactions.Drug discovery today. Disease models · 2018Article
- Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains.Frontiers in physiology · 2017Article
- R2d2 Drives Selfish Sweeps in the House Mouse.Molecular biology and evolution · 2016Article
- Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake.Frontiers in behavioral neuroscience · 2016Article
- Physical activity in adulthood: genes and mortality.Scientific reports · 2015Article
- Evolution of the additive genetic variance-covariance matrix under continuous directional selection on a complex behavioural phenotype.Proceedings. Biological sciences · 2015Article
- Genetic approaches in comparative and evolutionary physiology.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.PLoS genetics · 2015Article
- Humanized animal exercise model for clinical implication.Pflugers Archiv : European journal of physiology · 2014Review
- Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle.Physiological genomics · 2014Article
- Fine-mapping QTLs in advanced intercross lines and other outbred populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Differential skeletal muscle proteome of high- and low-active mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Differential gene expression in high- and low-active inbred mice.BioMed research international · 2014Article
- Article
- Host genetics and diet, but not immunoglobulin A expression, converge to shape compositional features of the gut microbiome in an advanced intercross population of mice.Genome biology · 2014Article
- Article
- Genetic determinants of voluntary exercise.Trends in genetics : TIG · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in are strikingly variable, even under prescription. Our focus was to identify the locations and effects of quantitative trait loci (QTL) controlling genetic predisposition for exercise-related traits, utilizing a large advanced intercross line (AIL) of mice. This AIL (G(4)) population originated from a reciprocal cross between mice with genetic propensity for increased voluntary exercise [high-runner (HR) line, selectively bred for increased wheel running] and the inbred strain C57BL/6J. After adjusting for family structure, we detected 32 significant and 13 suggestive QTL representing both daily running traits (distance, duration, average speed, and maximum speed) and the mean of these traits on days 5 and 6 (the selection criteria for HR) of a 6-day test conducted at 8 wk of age, with many co-localizing to similar genomic regions. Additionally, seven significant and five suggestive QTL were observed for the slope and intercept of a linear regression across all 6 days of running, some representing a combination of the daily traits. We also observed two significant and two suggestive QTL for body mass before exercise. These results, from a well-defined animal model, reinforce a genetic basis for the predisposition to engage in voluntary exercise, dissect this predisposition into daily segments across a continuous time period, and present unique QTL that may provide insight into the initiation, continuation, and temporal pattern of voluntary activity in mammals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.