ArticleFree radical biology & medicine2010
Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid.
Article in Free radical biology & medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 107 citations in OpenAlex.
- Nutrition intervention to decrease symptoms in patients with advanced heart failure.Research in nursing & health · 2013Trial
- Evaluation the Effect of Rosmarinic Acid as an Antioxidant Agent on Shear Bond Strength of Resin Composite to Bleached Enamel.Journal of clinical and experimental dentistry · 2025Article
- Cell Type-Specific Anti- and Pro-Oxidative Effects ofMembranes · 2024Article
- Pharmacological potentials of lycopene against aging and aging-related disorders: A review.Food science & nutrition · 2023Review
- Role of the renin-angiotensin system in the pathophysiology of coronary heart disease and heart failure: Diagnostic biomarkers and therapy with drugs and natural products.Frontiers in physiology · 2023Review
- Chronological age enhances aging phenomena and protein nitration in oocyte.Frontiers in endocrinology · 2023Article
- Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- Melatonin interferes with COVID-19 at several distinct ROS-related steps.Journal of inorganic biochemistry · 2021Review
- A Multiple-Hit Hypothesis Involving Reactive Oxygen Species and Myeloperoxidase Explains Clinical Deterioration and Fatality in COVID-19.International journal of biological sciences · 2021Review
- Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders.Antioxidants (Basel, Switzerland) · 2020Review
- Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Relation of Fruits and Vegetables with Major Cardiometabolic Risk Factors, Markers of Oxidation, and Inflammation.Nutrients · 2019Review
- Antioxidant capacity is repeatable across years but does not consistently correlate with a marker of peroxidation in a free-living passerine bird.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Extracts of Peels and Seeds of Five Varieties of Brazilian Jabuticaba Present High Capacity to Deactivate Reactive Species of Oxygen and Nitrogen.Plant foods for human nutrition (Dordrecht, Netherlands) · 2019Article
- The acute effects of walking exercise intensity on systemic cytokines and oxidative stress.European journal of applied physiology · 2018Article
- Development of small blood volume assays for the measurement of oxidative stress markers in mammals.PloS one · 2018Article
- Effects of Lycopene and Sodium Valproate on Pentylenetetrazol-Induced Kindling in Mice.Iranian journal of medical sciences · 2016Article
- Differences in the oxidative balance of dispersing and non-dispersing individuals: an experimental approach in a passerine bird.BMC evolutionary biology · 2016Article
- Lycopene as a carotenoid provides radioprotectant and antioxidant effects by quenching radiation-induced free radical singlet oxygen: an overview.Cell journal · 2015Review
- Melatonin prevents myeloperoxidase heme destruction and the generation of free iron mediated by self-generated hypochlorous acid.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Lycopene, a carotenoid found in tomatoes, is a proven antioxidant that may lower the risk of certain disorders including heart disease and cancer. Hypochlorous acid (HOCl) is an oxidant linked to tissue oxidation in cardiovascular disease and other inflammatory disorders through its ability to modify proteins, deoxyribonucleic acid, ribonucleic acid, and lipids. Here we show that lycopene can function as a potent scavenger of HOCl at a wide range of concentrations that span various pathophysiological and supplemental ranges. The oxidation of lycopene by HOCl was accompanied by a marked change in color, from red to colorless, of the lycopene solution, suggesting lycopene degradation. HPLC and LC-MS analysis showed that the exposure of lycopene to increasing concentrations of HOCl gave a range of metabolites resulting from oxidative cleavage of one or more C=C. The degree of degradation of lycopene (as assessed by the number and chain lengths of the various oxidative metabolites of lycopene) depends mainly on the ratio of HOCl to lycopene, suggesting that multiple molecules of HOCl are consumed per molecule of lycopene. Collectively, this work demonstrates a direct link between lycopene and HOCl scavenging and may assist in elucidating the mechanism of the protective function exerted by lycopene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.