Evidence map›Paper›PMID 20388499›Full record

ReviewBrain research2010

MicroRNAs in psychiatric and neurodevelopmental disorders.

Bin Xu, Maria Karayiorgou, Joseph A Gogos

Abstract readReview
In one paragraph

Review in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. miR-514a promotes neuronal development in human iPSC-derived neurons.Frontiers in cell and developmental biology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Observational
  17. Loss-of-function mutation inProceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  18. MicroRNA function in Drosophila memory formation.Current opinion in neurobiology · 2017
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bin XuDepartment of Physiology and Cellular Biophysics, Columbia University Medical Center, 630 W. 168th Street,New York, NY 10032, USA.
Maria Karayiorgou
Joseph A Gogos
Columbia University · US

Funding

Elucidation of gene networks underlying susceptibility to schizophreniaR01MH077235 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOGOS, JOSEPH A · 2007 to 2009
$1.3M
Understanding the genomic risk architecture of schizophrenia using gene expressioRC1MH088263 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOGOS, JOSEPH A · 2009 to 2010
$996k
NIMH NIH HHS R01 MH077235NIMH NIH HHS RC1 MH088263
6 · The paper itself

Abstract

Abnormalities in microRNA (miRNA)-mediated gene regulation have been observed in a variety of human diseases, especially in cancer. Here, we provide an account of newly emerging connections between miRNAs with various psychiatric and neurodevelopmental disorders, including recent findings of miRNA dysregulation in the 22q11.2 microdeletion syndrome, a well-established genetic risk factor for schizophrenia. miRNAs appear to be components of both the genetic architecture of these complex phenotypes as well as integral parts of the biological pathways that mediate the effects of primary genetic deficits. Therefore, they may contribute to both genetic heterogeneity and phenotypic variation of psychiatric and neurodevelopmental disorders and could serve as novel therapeutic targets.

Indexed as

AnimalsDevelopmental DisabilitiesHumansMental DisordersMicroRNAsModels, NeurologicalNervous System DiseasesMicroRNAs

Identifiers

PMID20388499
PMCPMC2883644
OpenAlexW2021626705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.