ReviewBrain research2010
The tempted brain eats: pleasure and desire circuits in obesity and eating disorders.
Review in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 344 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
344 citing papers in PubMed, 4 syntheses or guidelines pooled it, 868 citations in OpenAlex.
- Comparing body composition between the sweet-liking phenotypes: experimental data, systematic review and individual participant data meta-analysis.International journal of obesity (2005) · 2024Pooled it
- The cerebellum plays more than one role in the dysregulation of appetite: Review of structural evidence from typical and eating disorder populations.Brain and behavior · 2023Pooled it
- Pooled it
- The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A 'Ménage à Trois'?Alcohol and alcoholism (Oxford, Oxfordshire) · 2017Pooled it
- Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study.Nature metabolism · 2023Trial
- The Effect of a 14-DayNutrients · 2022Trial
- Targeted self-regulation interventions in low-income children: Clinical trial results and implications for health behavior change.Journal of experimental child psychology · 2021Trial
- Explicit and Implicit Responses to Tasting Drinks Associated with Different Tasting Experiences.Sensors (Basel, Switzerland) · 2019Trial
- Got chocolate? Bilateral prefrontal cortex stimulation augments chocolate consumption.Appetite · 2018Trial
- Dynamic fMRI networks predict success in a behavioral weight loss program among older adults.NeuroImage · 2018Trial
- Factors influencing the reinforcing value of fruit and unhealthy snacks.European journal of nutrition · 2017Trial
- Sweet taste liking is associated with subjective response to amphetamine in women but not men.Psychopharmacology · 2017Trial
- Frontostriatal and behavioral adaptations to daily sugar-sweetened beverage intake: a randomized controlled trial.The American journal of clinical nutrition · 2017Trial
- Satiety does not always silence attention to high-calorie foods: BMI modulates food-related attentional bias.International journal of obesity (2005) · 2026Article
- Feeding Behavior and Lipid Content Depend on Dopamine Level in Drosophila melanogaster.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2026Article
- Profiling Endogenous Opioid Peptide Release from Adrenal Chromaffin Cells.ACS chemical neuroscience · 2026Article
- Do GLP-1 Receptor Agonists Alter Brain Responses to Reward-Related Cues? A Systematic Review.bioRxiv : the preprint server for biology · 2026Article
- Disordered eating in early childhood: DRD2 and COMT gene polymorphisms and behavioral features in family trios.Eating and weight disorders : EWD · 2026Article
- Stress, well-being, and optimism in Portuguese youth: how do gender and age shape mental health and eating quality.Frontiers in psychology · 2026Article
- Decreasing attentional bias for food cues in satiated women with obesity: a pilot study examining feasibility and acceptability.Pilot and feasibility studies · 2025Article
284 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
What we eat, when and how much, all are influenced by brain reward mechanisms that generate "liking" and "wanting" for foods. As a corollary, dysfunction in reward circuits might contribute to the recent rise of obesity and eating disorders. Here we assess brain mechanisms known to generate "liking" and "wanting" for foods and evaluate their interaction with regulatory mechanisms of hunger and satiety, relevant to clinical issues. "Liking" mechanisms include hedonic circuits that connect together cubic-millimeter hotspots in forebrain limbic structures such as nucleus accumbens and ventral pallidum (where opioid/endocannabinoid/orexin signals can amplify sensory pleasure). "Wanting" mechanisms include larger opioid networks in nucleus accumbens, striatum, and amygdala that extend beyond the hedonic hotspots, as well as mesolimbic dopamine systems, and corticolimbic glutamate signals that interact with those systems. We focus on ways in which these brain reward circuits might participate in obesity or in eating disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.