ArticleAnnals of biomedical engineering2010
Neutrophil adhesion on endothelial cells in a novel asymmetric stenosis model: effect of wall shear stress gradients.
Article in Annals of biomedical engineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Empagliflozin mitigates endothelial inflammation and attenuates endoplasmic reticulum stress signaling caused by sustained glycocalyx disruption.Scientific reports · 2022Article
- In Vivo Pharmacodynamic Method to Assess Complement C5a Receptor Antagonist Efficacy.ACS pharmacology & translational science · 2022Article
- Emulating Early Atherosclerosis in a Vascular Microphysiological System Using Branched Tissue-Engineered Blood Vessels.Advanced biology · 2021Article
- Involvement of Matrix Metalloproteinase 9 in Vertebral Arterial Dissection With Posterior Circulation Ischemic Stroke.Journal of the American Heart Association · 2020Article
- 3D Immunocompetent Organ-on-a-Chip Models.Small methods · 2020Article
- Empagliflozin restores the integrity of the endothelial glycocalyx in vitro.Molecular and cellular biochemistry · 2019Article
- Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing.Biomaterials · 2019Review
- A tunable microfluidic 3D stenosis model to study leukocyte-endothelial interactions in atherosclerosis.APL bioengineering · 2018Article
- Increased MMP activity in curved geometries disrupts the endothelial cell glycocalyx creating a proinflammatory environment.PloS one · 2018Article
- Targeting cell adhesion molecules with nanoparticles using in vivo and flow-based in vitro models of atherosclerosis.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Microparticles in patients undergoing transcatheter aortic valve implantation (TAVI).Heart and vessels · 2017Article
- Flow of Red Blood Cells in Stenosed Microvessels.Scientific reports · 2016Article
- Glycocalyx Degradation Induces a Proinflammatory Phenotype and Increased Leukocyte Adhesion in Cultured Endothelial Cells under Flow.PloS one · 2016Article
- The effect of simvastatin treatment on endothelial cell response to shear stress and tumor necrosis factor alpha stimulation.Biomedical engineering online · 2015Article
- Adhesion patterns in the microvasculature are dependent on bifurcation angle.Microvascular research · 2015Article
- Nitric oxide transport in an axisymmetric stenosis.Journal of the Royal Society, Interface · 2012Article
- Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature.Microvascular research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Leukocytes play a pivotal role in the progression of atherosclerosis. A novel three-dimensional in vitro asymmetric stenosis model was used to better investigate the role of local hemodynamics in the adhesion of leukocytes to an established plaque. The adhesion of a human promyelocytic cell line (NB4) on a human abdominal aortic endothelial cell (EC) monolayer was quantified. NB4 cells were circulated over TNF-alpha stimulated and nonstimulated ECs for 1 or 6 h at 1.25 or 6.25 dynes/cm(2) and compared to static conditions. Cytokine stimulation increased significantly EC expression of intercellular adhesion molecule and vascular cell adhesion molecule. Under static conditions, neutrophils adhered overall more than under flow, with decreased adhesion with increasing shear. Adhesion was significantly higher in the recirculation region distal to the stenosis than in the inlet. Preshearing the ECs decreased the expression of cell adhesion molecules in inflamed endothelium and significantly decreased adhesion. However, the ratio of adhesion between the recirculation zone and the inlet increased, hence exhibiting an increased regional difference. This work suggests an important role for neutrophil-EC interactions in the atherosclerotic process, especially in wall shear stress gradient regions. This is important clinically, potentially helping to explain plaque stability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.