ArticleInternational urology and nephrology2011
Correlation between cathepsin D serum concentration and carotid intima-media thickness in hemodialysis patients.
Article in International urology and nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Plasma and cerebrospinal fluid proteomic signatures of acutely sleep-deprived humans: an exploratory study.Sleep advances : a journal of the Sleep Research Society · 2023Article
- Investigation of the Relationship between Cardiovascular Biomarkers and Brachial-Ankle Pulse Wave Velocity in Hemodialysis Patients.Journal of personalized medicine · 2022Article
- Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice.Frontiers in immunology · 2021Article
- The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach.European journal of heart failure · 2020Article
- Inhibiting Extracellular Cathepsin D Reduces Hepatic Steatosis in Sprague⁻Dawley RatsBiomolecules · 2019Article
- Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure.Circulation. Heart failure · 2017Article
- The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease.Frontiers in cell and developmental biology · 2017Review
- Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.Disease markers · 2017Article
- Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention.Scientific reports · 2016Article
- Plasma cathepsin D levels: a novel tool to predict pediatric hepatic inflammation.The American journal of gastroenterology · 2015Article
- Evaluation of serum cathepsin D concentrations in coronary artery disease.Indian heart journalArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimCardiovascular (CV) disease is the leading cause of death in hemodialysis (HD) patients, and approximately half of mortalities in HD patients are attributed to CV disease. Atherosclerosis is the most frequent cause of CV complications in patients with end-stage renal disease (ESRD). Based on recent studies, cathepsin D has been suggested as a potential marker of atherosclerosis, and we hypothesized that there is an association between serum concentration of cathepsin D and carotid intima-media thickness (CIMT) in hemodialysis patients.
methodsThirty-one hemodialysis patients (18 men and 13 women) were enrolled in this study. Serum levels of soluble cathepsin D were measured with an enzyme-linked immunosorbant assay (ELISA) kit. CIMT was determined in each patient.
resultsThe data showed that there was a positive significant correlation between serum concentration of cathepsin D and CIMT by using Pearson correlation (P value <0.05).
conclusionBased on the results of this study, cathepsin D could be suggested to have a role in the development of atherosclerotic plaques.
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