ReviewCerebellum (London, England)2012
Glutamate-receptor-like molecule GluRδ2 involved in synapse formation at parallel fiber-Purkinje neuron synapses.
Review in Cerebellum (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction.Acta pharmacologica Sinica · 2026Review
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Lurcher Mouse as a Model of Cerebellar Syndromes.Cerebellum (London, England) · 2025Review
- Ultrastructural Localization of Glutamate Delta Receptor 1 in the Rodent and Primate Lateral Habenula.The Journal of comparative neurology · 2025Article
- Ultrastructural localization of glutamate delta 1 (GluD1) receptor immunoreactivity in the mouse and monkey striatum.The Journal of comparative neurology · 2021Article
- Role of actin cytoskeleton in the organization and function of ionotropic glutamate receptors.Current research in structural biology · 2021Review
- Altered Glutamate Receptor Ionotropic Delta Subunit 2 Expression in Stau2-Deficient Cerebellar Purkinje Cells in the Adult Brain.International journal of molecular sciences · 2019Article
- Early Disruption of Extracellular Pleiotrophin Distribution Alters Cerebellar Neuronal Circuit Development and Function.Molecular neurobiology · 2016Article
- Electrophysiological properties of NG2(+) cells: Matching physiological studies with gene expression profiles.Brain research · 2016Review
- Contribution of postsynaptic GluD2 to presynaptic R-type Ca(2+) channel function, glutamate release and long-term potentiation at parallel fiber to Purkinje cell synapses.Cerebellum (London, England) · 2013Article
- Glutamate receptor δ2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase Cγ, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Diversity and complexity of roles of granule cells in the cerebellar cortex. Editorial.Cerebellum (London, England) · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate-receptor-like molecule δ2 (GluRδ2, GluD2) has been classified as an ionotropic glutamate receptor subunit. It is selectively expressed on the postsynaptic membrane at parallel fiber-Purkinje neuron synapses in the cerebellum. Mutant mice deficient in GluRδ2 show impaired synaptic plasticity, the decrease in the number of parallel fiber-Purkinje neuron synapses, multiple innervation of climbing fibers on a Purkinje neuron, and defects in motor control and learning. Thus, GluRδ2 plays crucial roles in the cerebellar function. Recent studies on GluRδ2 have shown that it has synaptogenic activity. GluRδ2 expressed in a non-neuronal cell induces presynaptic differentiation of granule neurons in a co-culture preparation. This synaptogenic activity depends on an extracellular N-terminal leucine/isoleucine/valine binding protein-like domain of GluRδ2. GluRδ2 plays critical roles in formation, maturation, and/or maintenance of granule neuron-Purkinje neuron synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.