ArticleJournal of molecular neuroscience : MN2010
Comparison of intestinal warm ischemic injury in PACAP knockout and wild-type mice.
Article in Journal of molecular neuroscience : MN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of PACAP Deficiency on Immune Dysfunction and Peyer's Patch Integrity in Adult Mice.International journal of molecular sciences · 2024Article
- Neurochemistry of Enteric Neurons Following Prolonged Indomethacin Administration in the Porcine Duodenum.Frontiers in pharmacology · 2020Article
- Protective Effects of PACAP in Peripheral Organs.Frontiers in endocrinology · 2020Review
- Targeting the PAC1 Receptor for Neurological and Metabolic Disorders.Current topics in medicinal chemistry · 2019Review
- PACAP deficiency as a model of aging.GeroScience · 2018Review
- Protective effects of PACAP in ischemia.The journal of headache and pain · 2018Review
- Molecular mechanisms underlying the Nephroprotective effects of PACAP in diabetes.Journal of molecular neuroscience : MN · 2014Article
- Comparative protein composition of the brains of PACAP-deficient mice using mass spectrometry-based proteomic analysis.Journal of molecular neuroscience : MN · 2014Article
- Examination of calcium-binding protein expression in the inner ear of wild-type, heterozygous and homozygous pituitary adenylate cyclase-activating polypeptide (PACAP)-knockout mice in kanamycin-induced ototoxicity.Neurotoxicity research · 2014Article
- Changes of PACAP immunoreactivities and cytokine levels after PACAP-38 containing intestinal preservation and autotransplantation.Journal of molecular neuroscience : MN · 2012Article
- Changes in pituitary adenylate cyclase-activating Peptide 27-like immunoreactive nervous structures in the porcine descending colon during selected pathological processes.Journal of molecular neuroscience : MN · 2012Article
- Effects of pituitary adenylate cyclase activating polypeptide on human sperm motility.Journal of molecular neuroscience : MN · 2012Article
- PACAP is an endogenous protective factor-insights from PACAP-deficient mice.Journal of molecular neuroscience : MN · 2012Article
- Comparative examination of inner ear in wild type and pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.Neurotoxicity research · 2012Article
- Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo.Neurotoxicity research · 2012Article
- VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies.Current opinion in endocrinology, diabetes, and obesity · 2011Review
- Effects of PACAP on oxidative stress-induced cell death in rat kidney and human hepatocyte cells.Journal of molecular neuroscience : MN · 2011Article
- Comparison of Surgical and Cadaveric Intestine as a Source of Crypt Culture in Humans.Cell transplantationArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pituitary adenylate cyclase-activating polypeptide (PACAP) is present in the gastrointestinal tract and plays a central role in the intestinal physiology, mainly in the secretion and motility. The aim of our study was to compare the ischemic injury in wild-type and PACAP-38 knockout mice following warm mesenteric small bowel ischemia. Warm ischemia groups were designed with occlusion of superior mesenteric artery for 1, 3, and 6 h in wild-type (n = 10 in each group) and PACAP-38 knockout (n = 10 in each group) mice. Small bowel biopsies were collected after laparotomy (control) and at the end of the ischemia periods. To determine oxidative stress parameters, malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD) were measured. Tissue damage was analyzed by qualitative and quantitative methods on hematoxylin/eosin-stained sections. In PACAP-38 knockout animals, tissue MDA increased significantly after 3 and 6 h ischemia (133.97 ± 6,2; 141.86 ± 5,8) compared to sham-operated (100.92 ± 3,6) and compared to wild-type results (112.8 ± 2,1; 118.4 ± 1.03 μmol/g, p < 0.05). Meanwhile, tissue concentration of GSH and activity of SOD decreased significantly in knockout mice compared to wild-type form (GSH, 795.97 ± 10.4; 665.1 ± 8,8 vs. 893.23 ± μmol/g; SOD, 94.4 ± 1.4; 81.2 ± 3.9 vs. 208.09 ± 3,7 IU/g). Qualitative and quantitative histological results showed destruction of the mucous, submucous layers, and crypts in knockout mice compared to wild-type tissues. These processes correlated with the warm ischemia periods. Our present results propose an important protective effect of endogenous PACAP-38 against intestinal warm ischemia, which provides basis for further investigation to elucidate the mechanism of this protective effect.
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