ReviewPediatric nephrology (Berlin, Germany)2010
Genetic studies of IgA nephropathy: past, present, and future.
Review in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 92 citations in OpenAlex.
- Novel Findings on the Development and Immunological Functions of Palatine Tonsils.Clinical reviews in allergy & immunology · 2025Review
- Genetics of IgA nephrology: risks, mechanisms, and therapeutic targets.Pediatric nephrology (Berlin, Germany) · 2024Review
- Analysis of a Familial IgAN Accompanied by COL4A3 Mutation.Journal of inflammation research · 2024Article
- Review
- NovelWorld journal of clinical cases · 2023Article
- Epigenome-wide association study and network analysis for IgA Nephropathy from CD19Epigenetics · 2021Article
- Is IgA nephropathy the same disease in different parts of the world?Seminars in immunopathology · 2021Review
- Positive renal familial history in IgA nephropathy is associated with worse renal outcomes: a single-center longitudinal study.BMC nephrology · 2021Observational
- Rare Collagenous Heterozygote Variants in Children With IgA Nephropathy.Kidney international reports · 2021Article
- Increased Lifetime Risk of ESRD in Familial IgA Nephropathy.Kidney international reports · 2021Article
- CMIP SNPs and their haplotypes are associated with dyslipidaemia and clinicopathologic features of IgA nephropathy.Bioscience reports · 2020Article
- Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy.Disease markers · 2020Article
- Autoantibodies Specific for Galactose-Deficient IgA1 in IgA Vasculitis With Nephritis.Kidney international reports · 2019Article
- Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans.BMC medical genomics · 2019Article
- Common Mechanisms of Viral Injury to the Kidney.Advances in chronic kidney disease · 2019Review
- The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy.Frontiers in immunology · 2019Review
- Effects of Periostracum Cicadae on Cytokines and Apoptosis Regulatory Proteins in an IgA Nephropathy Rat Model.International journal of molecular sciences · 2018Article
- Multiple rare genetic variants co-segregating with familial IgA nephropathy all act within a single immune-related network.Journal of internal medicine · 2017Article
- IgA1 Glycosylation Is Heritable in Healthy Twins.Journal of the American Society of Nephrology : JASN · 2017Article
- New developments in the genetics, pathogenesis, and therapy of IgA nephropathy.Kidney international · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and an important cause of kidney disease in young adults. Highly variable clinical presentation and outcome of IgAN suggest that this diagnosis may encompass multiple subsets of disease that are not distinguishable by currently available clinical tools. Marked differences in disease prevalence between individuals of European, Asian, and African ancestry suggest the existence of susceptibility genes that are present at variable frequencies in these populations. Familial forms of IgAN have also been reported throughout the world but are probably underrecognized because associated urinary abnormalities are often intermittent in affected family members. Of the many pathogenic mechanisms reported, defects in IgA1 glycosylation that lead to formation of immune complexes have been consistently demonstrated. Recent data indicates that these IgA1 glycosylation defects are inherited and constitute a heritable risk factor for IgAN. Because of the complex genetic architecture of IgAN, the efforts to map disease susceptibility genes have been difficult, and no causative mutations have yet been identified. Linkage-based approaches have been hindered by disease heterogeneity and lack of a reliable noninvasive diagnostic test for screening family members at risk of IgAN. Many candidate-gene association studies have been published, but most suffer from small sample size and methodological problems, and none of the results have been convincingly validated. New genomic approaches, including genome-wide association studies currently under way, offer promising tools for elucidating the genetic basis of IgAN.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.