ArticlePediatric nephrology (Berlin, Germany)2010
No juvenile arterial hypertension in sheep multiples despite reduced nephron numbers.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Maternal under-nutrition during pregnancy alters the molecular response to over-nutrition in multiple organs and tissues in nonhuman primate juvenile offspring.Journal of developmental origins of health and disease · 2024Article
- Postnatal persistence of nonhuman primate sex-dependent renal structural and molecular changes programmed by intrauterine growth restriction.Journal of medical primatology · 2022Article
- Different levels of cardiometabolic indicators in multiple vs. singleton children.BMC pediatrics · 2019Article
- Developmental Programming of Renal Function and Re-Programming Approaches.Frontiers in pediatrics · 2018Review
- Development of nonfibrotic left ventricular hypertrophy in an ANG II-induced chronic ovine hypertension model.Physiological reports · 2016Article
- Ovine fetal renal development impacted by multiple fetuses and uterine space restriction.Journal of developmental origins of health and disease · 2013Article
- Comparative proteomic analysis of kidney development-related proteins in the pig.In vitro cellular & developmental biology. Animal · 2013Article
- Developmental origins of chronic renal disease: an integrative hypothesis.International journal of nephrology · 2013Review
- Low nephron number and its clinical consequences.Rambam Maimonides medical journal · 2011Article
- Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues.Pediatric nephrology (Berlin, Germany) · 2011Review
- Factors modifying the association between birth weight and blood pressure.Pediatric nephrology (Berlin, Germany) · 2010Article
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7 authors.
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Abstract
Low birth weight is associated with an increased risk of metabolic dysfunction and arterial hypertension in later life. Because of their reduced birth weight twins have been used repeatedly as a natural model to investigate prenatal programming of hypertension. To reveal an early impact of lower nephron endowment on blood pressure, we performed a longitudinal study on lambs from single, twin and triplet pregnancies. The lambs were studied from birth until adulthood, including regular blood analyses, measurements of body weight and blood pressure and post-mortem estimation of glomerular numbers. Relative weight differences between multiples and singletons at birth were -28% for twins and -44% for triplets, respectively. Some lambs showed rapid catch-up growth. Total nephron number of twins and triplets was reduced by 21 and 37% with respect to that of singletons (p < 0.01). However, multiples did not show increased blood pressure within the time frame of this study. No gender-specific effect was observed. Plasma concentrations of creatinine, urea, electrolytes or osmolality also did not differ. Our data indicate that the previously reported postnatal blood pressure differences between sheep multiples and singletons are a time-limited phenomenon. During infancy and adolescence, a reduced nephron number in sheep multiples is neither associated with increased blood pressure nor reflected by plasma parameters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.