ArticleDiabetologia2010
The role of transmembrane protein 27 (TMEM27) in islet physiology and its potential use as a beta cell mass biomarker.
Article in Diabetologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 32 citations in OpenAlex.
- Active targeting of type 1 diabetes therapies to pancreatic beta cells using nanocarriers.Diabetologia · 2025Review
- Comprehensive bioinformatics analysis identifies metabolic and immune-related diagnostic biomarkers shared between diabetes and COPD using multi-omics and machine learning.Frontiers in endocrinology · 2024Article
- Sex differences in islet stress responses support female β cell resilience.Molecular metabolism · 2023Article
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- Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology.Advances in experimental medicine and biology · 2021Review
- SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth.Frontiers in endocrinology · 2021Article
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- Molecular imaging of β-cells: diabetes and beyond.Advanced drug delivery reviews · 2019Review
- The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans.The Journal of clinical endocrinology and metabolism · 2018Article
- Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma.Journal of cancer research and clinical oncology · 2016Article
- Genetic models rule out a major role of beta cell glycogen in the control of glucose homeostasis.Diabetologia · 2016Article
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- ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice.American journal of physiology. Endocrinology and metabolism · 2015Article
- Role of collectrin, an ACE2 homologue, in blood pressure homeostasis.Current hypertension reports · 2014Review
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- Glucose regulation of a cell cycle gene module is selectively lost in mouse pancreatic islets during ageing.Diabetologia · 2013Article
- Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.Stem cell research · 2013Article
- The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice.Diabetologia · 2012Article
- Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).Diabetologia · 2012Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisTransmembrane protein 27 (TMEM27) is a membrane protein cleaved and shed by pancreatic beta cells that has been proposed as a beta cell mass biomarker. Despite reports of its possible role in insulin exocytosis and cell proliferation, its function in beta cells remains controversial. We aimed to characterise the function of TMEM27 in islets and its potential use as a beta cell mass biomarker.
methodsTo determine TMEM27 function, we studied TMEM27 gene expression and localisation in human healthy and diabetic islets, the correlation of its expression with cell cycle and insulin secretion genes in human islets, its expression in tungstate-treated rats, and the effects of its overproduction on insulin secretion and proliferation in a beta cell line and islets. To elucidate its utility as a beta cell mass biomarker, we studied TMEM27 cleavage in a beta cell line, islets and primary proximal tubular cells.
resultsTMEM27 mRNA levels in islets are lower in diabetic donors than in controls. Its gene expression correlates with that of insulin and SNAPIN in human islets. TMEM27 expression is downregulated in islets of tungstate-treated rats, which exhibit decreased insulin secretion and increased proliferation. TMEM27 overproduction in a beta cell line and islets significantly enhanced glucose-induced insulin secretion, with modest or no effects on proliferation. Finally, TMEM27 is cleaved and shed by renal proximal tubular cells and pancreatic islets. CONCLUSIONS/
interpretationOur data support a role for TMEM27 in glucose-induced insulin secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker.
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