ArticlePloS one2010
Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Molecular characterization and functional insights of secondary hair follicles across the cashmere growth cycle.BMC genomics · 2026Article
- Hair follicle organoids: advances in construction, applications, and translational challenges.Frontiers in cell and developmental biology · 2026Review
- Deep Hair Phenomics: Implications in Endocrinology, Development, and Aging.The Journal of investigative dermatology · 2025Article
- Integration Analysis of Transcriptome Sequencing and Whole-Genome Resequencing Reveal Wool Quality-Associated Key Genes in Zhexi Angora Rabbits.Veterinary sciences · 2024Article
- Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition.Communications biology · 2024Article
- Compound heterozygous WNT10A missense variations exacerbated the tooth agenesis caused by hypohidrotic ectodermal dysplasia.BMC oral health · 2024Article
- Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways.Frontiers in pharmacology · 2024Article
- Article
- Somitic positional information guides self-organized patterning of snake scales.Science advances · 2023Article
- Discovery and Functional Analysis of Secondary Hair Follicle miRNAs during Annual Cashmere Growth.International journal of molecular sciences · 2023Article
- The Role of Ectodysplasin A on the Ocular Surface Homeostasis.International journal of molecular sciences · 2022Review
- Mining the 99 Lives Cat Genome Sequencing Consortium database implicates genes and variants for the Ticked locus in domestic cats (Felis catus).Animal genetics · 2021Article
- A worldwide map of swine short tandem repeats and their associations with evolutionary and environmental adaptations.Genetics, selection, evolution : GSE · 2021Article
- A literature review on function and regulation mechanism of DKK4.Journal of cellular and molecular medicine · 2021Review
- Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis.Frontiers in cell and developmental biology · 2021Review
- Transcriptomic Analysis Reveals the Involvement of lncRNA-miRNA-mRNA Networks in Hair Follicle Induction in Aohan Fine Wool Sheep Skin.Frontiers in genetics · 2020Article
- Generation of Cashmere Goats Carrying anInternational journal of biological sciences · 2018Article
- Hierarchical patterning modes orchestrate hair follicle morphogenesis.PLoS biology · 2017Article
- Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.Development (Cambridge, England) · 2016Article
- Earlier-born secondary hair follicles exhibit phenotypic plasticity.Experimental dermatology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The mouse hair coat comprises protective "primary" and thermo-regulatory "secondary" hairs. Primary hair formation is ectodysplasin (Eda) dependent, but it has been puzzling that Tabby (Eda(-/y)) mice still make secondary hair. We report that Dickkopf 4 (Dkk4), a Wnt antagonist, affects an auxiliary pathway for Eda-independent development of secondary hair. A Dkk4 transgene in wild-type mice had no effect on primary hair, but secondary hairs were severely malformed. Dkk4 action on secondary hair was further demonstrated when the transgene was introduced into Tabby mice: the usual secondary follicle induction was completely blocked. The Dkk4-regulated secondary hair pathway, like the Eda-dependent primary hair pathway, is further mediated by selective activation of Shh. The results thus reveal two complex molecular pathways that distinctly regulate subtype-based morphogenesis of hair follicles, and provide a resolution for the longstanding puzzle of hair formation in Tabby mice lacking Eda.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.