ArticlePLoS biology2010
Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons.
Article in PLoS biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- The Role and Mechanisms of G protein-coupled receptors in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sex-dependent alterations in behavior, drug responses and dopamine transporter expression in heterozygous DAT-Cre mice.Scientific reports · 2021Article
- Shining light on cysteine modification: connecting protein conformational dynamics to catalysis and regulation.Journal of synchrotron radiation · 2019Article
- Sensory neuropathy and nociception in rodent models of Parkinson's disease.Disease models & mechanisms · 2019Review
- Review
- Peripheral Administration of Tetanus Toxin Hc Fragment Prevents MPPNeurotoxicity research · 2018Article
- Cytoprotective mechanisms of DJ-1 against oxidative stress through modulating ERK1/2 and ASK1 signal transduction.Redox biology · 2018Review
- Regulation of Signal Transduction by DJ-1.Advances in experimental medicine and biology · 2017Article
- Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.Cell death & disease · 2016Article
- The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system.Neural regeneration research · 2015Article
- Crosstalk of parkin and Ret in dopaminergic neurons.Oncotarget · 2015Article
- Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration.The Journal of clinical investigation · 2015Article
- p38 MAPK and PI3K/AKT Signalling Cascades inParkinson's Disease.International journal of molecular and cellular medicine · 2015Review
- The role of DJ-1 in the oxidative stress cell death cascade after stroke.Neural regeneration research · 2014Review
- RET revisited: expanding the oncogenic portfolio.Nature reviews. Cancer · 2014Review
- Oxygen-glucose-deprived rat primary neural cells exhibit DJ-1 translocation into healthy mitochondria: a potent stroke therapeutic target.CNS neuroscience & therapeutics · 2014Article
- Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants.The EMBO journal · 2014Article
- DJ-1 ameliorates ischemic cell death in vitro possibly via mitochondrial pathway.Neurobiology of disease · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms underlying the selective death of substantia nigra (SN) neurons in Parkinson disease (PD) remain elusive. While inactivation of DJ-1, an oxidative stress suppressor, causes PD, animal models lacking DJ-1 show no overt dopaminergic (DA) neuron degeneration in the SN. Here, we show that aging mice lacking DJ-1 and the GDNF-receptor Ret in the DA system display an accelerated loss of SN cell bodies, but not axons, compared to mice that only lack Ret signaling. The survival requirement for DJ-1 is specific for the GIRK2-positive subpopulation in the SN which projects exclusively to the striatum and is more vulnerable in PD. Using Drosophila genetics, we show that constitutively active Ret and associated Ras/ERK, but not PI3K/Akt, signaling components interact genetically with DJ-1. Double loss-of-function experiments indicate that DJ-1 interacts with ERK signaling to control eye and wing development. Our study uncovers a conserved interaction between DJ-1 and Ret-mediated signaling and a novel cell survival role for DJ-1 in the mouse. A better understanding of the molecular connections between trophic signaling, cellular stress and aging could uncover new targets for drug development in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.