ReviewInternational journal of molecular sciences2010
Novel neuroprotective strategies in ischemic retinal lesions.
Review in International journal of molecular sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Exosome-loaded degradable polymeric microcapsules for the treatment of vitreoretinal diseases.Nature biomedical engineering · 2024Article
- Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors in Diabetic Retinopathy: An Attractive but Elusive Choice for Drug Development.Pharmaceutics · 2024Review
- Caffeine and Its Neuroprotective Role in Ischemic Events: A Mechanism Dependent on Adenosine Receptors.Cellular and molecular neurobiology · 2022Review
- Proteomics-Based Retinal Target Engagement Analysis and Retina-Targeted Delivery of 17β-Estradiol by the DHED Prodrug for Ocular Neurotherapy in Males.Pharmaceutics · 2021Article
- Relation of Retinal Oxygen Measures to Electrophysiology and Survival Indicators after Permanent, Incomplete Ischemia in Rats.Translational stroke research · 2020Article
- Protective effects of PACAP in ischemia.The journal of headache and pain · 2018Review
- Neuroprotective effects of erythropoietin on rat retinas subjected to oligemia.Clinics (Sao Paulo, Brazil) · 2018Article
- Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO).PloS one · 2018Article
- The Protective Role of PAC1-Receptor Agonist Maxadilan in BCCAO-Induced Retinal Degeneration.Journal of molecular neuroscience : MN · 2016Article
- PACAP application improves functional outcome of chronic retinal ischemic injury in rats-evidence from electroretinographic measurements.Journal of molecular neuroscience : MN · 2014Article
- Examination of calcium-binding protein expression in the inner ear of wild-type, heterozygous and homozygous pituitary adenylate cyclase-activating polypeptide (PACAP)-knockout mice in kanamycin-induced ototoxicity.Neurotoxicity research · 2014Article
- Gender-dependent effects of enriched environment and social isolation in ischemic retinal lesion in adult rats.International journal of molecular sciences · 2013Article
- PACAP protects against salsolinol-induced toxicity in dopaminergic SH-SY5Y cells: implication for Parkinson's disease.Journal of molecular neuroscience : MN · 2013Article
- Protective effects of vasoactive intestinal peptide (VIP) in ischemic retinal degeneration.Journal of molecular neuroscience : MN · 2012Article
- Effects of PACAP on intracellular signaling pathways in human retinal pigment epithelial cells exposed to oxidative stress.Journal of molecular neuroscience : MN · 2012Article
- Preconditioning with volatile anaesthetic sevoflurane in ischemic retinal lesion in rats.Journal of molecular histology · 2012Article
- Comparative examination of inner ear in wild type and pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.Neurotoxicity research · 2012Article
- Distribution and protective function of pituitary adenylate cyclase-activating polypeptide in the retina.Frontiers in endocrinology · 2012Article
- Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo.Neurotoxicity research · 2012Article
- Effects of PACAP in UV-A radiation-induced retinal degeneration models in rats.Journal of molecular neuroscience : MN · 2011Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K(+) channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.