ArticlePloS one2010
Pepper mild mottle virus, a plant virus associated with specific immune responses, Fever, abdominal pains, and pruritus in humans.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 85 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 211 citations in OpenAlex.
- Antiviral activity and mechanism of purine morpholine nucleoside analogues incorporating a sulfonamide fragment.Journal of advanced research · 2026Article
- An Immunochromatographic Test Strip and Its Application in Rapid Screening of Pepper Mild Mottle Virus.Biosensors · 2026Article
- Pathogens without borders: a review on cross-kingdom transmission strategies and pathogenicity of plant and human pathogens.Archives of microbiology · 2026Review
- High-throughput sequencing reveals the virome characteristics of wastewater in Gansu Province, China from 2024 to 2026.Frontiers in microbiology · 2026Article
- Article
- A tombus-like virus in patients with lower respiratory tract infection: an observational study based on meta-transcriptomic sequencing.Emerging microbes & infections · 2025Observational
- Utilities of PMMoV as an internal control for the building-level wastewater surveillance of SARS-CoV-2.Microbiology spectrum · 2025Article
- Optimizing solid-based methods for SARS-CoV-2 detection in wastewater: addressing PCR inhibition and variant challenges.Applied and environmental microbiology · 2025Article
- Detection of Hemagglutinin H5 Influenza A Virus RNA and Model of Potential Inputs in an Urban California Sewershed.Environmental science & technology · 2025Article
- Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease.Nature metabolism · 2025Article
- Hydrological and physicochemical parameters associated with SARS-CoV-2 and pepper mild mottle virus wastewater concentrations for a large-combined sewer system.Journal of water and health · 2025Article
- Alterations of the gut microbiome in HIV infection highlight human anelloviruses as potential predictors of immune recovery.Microbiome · 2024Article
- Juruaça virus taxonomy, tolerance and resistance to infection, and inflammatory response modulation in murine model.Npj viruses · 2024Article
- Advancements in Green Nanoparticle Technology: Focusing on the Treatment of Clinical Phytopathogens.Biomolecules · 2024Review
- Analysis of Coinfection Pathogens From Foot-and-Mouth Disease Virus Persistently Infected Cattle Using Oxford Nanopore Sequencing.Transboundary and emerging diseases · 2024Article
- Exploring the Human Virome: Composition, Dynamics, and Implications for Health and Disease.Current microbiology · 2023Review
- Metagenomic analysis of herbivorous mammalian viral communities in the Northwest Plateau.BMC genomics · 2023Article
- The Tomato Brown Rugose Fruit Virus Movement Protein Gene Is a Novel Microbial Source Tracking Marker.Applied and environmental microbiology · 2023Article
- Searching for a Reliable Viral Indicator of Faecal Pollution in Aquatic Environments.Journal of microbiology (Seoul, Korea) · 2023Review
- Monitoring Enteroviruses and SARS-CoV-2 in Wastewater Using the Polio Environmental Surveillance System in Japan.Applied and environmental microbiology · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
- Expression of concern · 2022-12-13Investigation by Journal/Publisher ·
- Erratum issued
- Expression of concern
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, metagenomic studies have identified viable Pepper mild mottle virus (PMMoV), a plant virus, in the stool of healthy subjects. However, its source and role as pathogen have not been determined. METHODS AND
findings21 commercialized food products containing peppers, 357 stool samples from 304 adults and 208 stool samples from 137 children were tested for PMMoV using real-time PCR, sequencing, and electron microscopy. Anti-PMMoV IgM antibody testing was concurrently performed. A case-control study tested the association of biological and clinical symptoms with the presence of PMMoV in the stool. Twelve (57%) food products were positive for PMMoV RNA sequencing. Stool samples from twenty-two (7.2%) adults and one child (0.7%) were positive for PMMoV by real-time PCR. Positive cases were significantly more likely to have been sampled in Dermatology Units (p<10(-6)), to be seropositive for anti-PMMoV IgM antibodies (p = 0.026) and to be patients who exhibited fever, abdominal pains, and pruritus (p = 0.045, 0.038 and 0.046, respectively).
conclusionsOur study identified a local source of PMMoV and linked the presence of PMMoV RNA in stool with a specific immune response and clinical symptoms. Although clinical symptoms may be imputable to another cofactor, including spicy food, our data suggest the possibility of a direct or indirect pathogenic role of plant viruses in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.