ArticlePediatric research2010
Mast cells mediate hyperoxia-induced airway hyper-reactivity in newborn rats.
Article in Pediatric research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?The Journal of pediatrics · 2017Review
- Early exposure to hyperoxia or hypoxia adversely impacts cardiopulmonary development.American journal of respiratory cell and molecular biology · 2015Article
- Perinatal factors in neonatal and pediatric lung diseases.Expert review of respiratory medicine · 2013Article
- Intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity in neonatal rats.Pediatric research · 2013Article
- Genome-wide transcriptional profiling reveals connective tissue mast cell accumulation in bronchopulmonary dysplasia.American journal of respiratory and critical care medicine · 2012Article
- Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring.American journal of respiratory cell and molecular biology · 2012Article
Corrections and comments
- Retraction · 2015-03-17Author Unresponsive · Criminal Proceedings · Investigation by Company/Institution · Unreliable Results and/or Conclusions · · EN Potts aka EN Potts-Kant;
- Commented on by
- Retracted
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Premature infants are at increased risk of developing airway hyper-reactivity (AHR) after oxidative stress and inflammation. Mast cells contribute to AHR partly by mediator release, so we sought to determine whether blocking mast cell degranulation or recruitment prevents hyperoxia-induced AHR, mast cell accumulation, and airway smooth muscle (ASM) changes. Rats were exposed at birth to air or 60% O2 for 14 d, inducing significantly increased AHR in the latter group, induced by nebulized methacholine challenge and measured by forced oscillometry. Daily treatment (postnatal d 1-14) with intraperitoneal cromolyn prevented hyperoxia-induced AHR, as did treatment with imatinib on postnatal d 5-14, compared with vehicle treated controls. Cromolyn prevented mast cell degranulation in the trachea but not hilar airways and blocked mast cell accumulation in the hilar airways. Imatinib treatment completely blocked mast cell accumulation in tracheal/hilar airway tissues. Hyperoxia-induced AHR in neonatal rats is mediated, at least in part, via the mast cell.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.