ArticleEpidemiology (Cambridge, Mass.)2010
The effect of HAART on HIV RNA trajectory among treatment-naïve men and women: a segmental Bernoulli/lognormal random effects model with left censoring.
Article in Epidemiology (Cambridge, Mass.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Trial
- Antifungal Susceptibility andBiomedicines · 2024Article
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- Modeling an integrated HIV prevention and care continuum to achieve the Ending the HIV Epidemic goals.AIDS (London, England) · 2020Article
- The Changing Science of HIV Epidemiology in the United States.American journal of epidemiology · 2019Review
- Effectiveness of combination packages for HIV-1 prevention in sub-Saharan Africa depends on partnership network structure: a mathematical modelling study.Sexually transmitted infections · 2016Article
- Serum Albumin Concentrations in a Multi-Ethnic Cohort of Patients with Human Immunodeficiency Virus Infection from South East London.BioResearch open access · 2015Article
- Community viral load as a measure for assessment of HIV treatment as prevention.The Lancet. Infectious diseases · 2013Article
- Analysis of cigarette purchase task instrument data with a left-censored mixed effects model.Experimental and clinical psychopharmacology · 2013Article
- Estimation of HIV incidence using multiple biomarkers.American journal of epidemiology · 2013Article
- Bayesian inference for skew-normal mixture models with left-censoring.Journal of biopharmaceutical statistics · 2013Article
- Estimation and inference on correlations between biomarkers with repeated measures and left-censoring due to minimum detection levels.Statistics in medicine · 2012Article
- Interleukin 10 responses are associated with sustained CD4 T-cell counts in treated HIV infection.The Journal of infectious diseases · 2012Article
- Article
- Opening the black box of biomarker measurement error.Epidemiology (Cambridge, Mass.) · 2010Article
- Estimating the odds ratio when exposure has a limit of detection.International journal of epidemiology · 2009Article
- The Use of Multiple Imputation for Data Subject to Limits of Detection.Sri Lankan journal of applied statisticsArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundHighly active antiretroviral therapy (HAART) rapidly suppresses human immunodeficiency virus (HIV) viral replication and reduces circulating viral load, but the long-term effects of HAART on viral load remain unclear.
methodsWe evaluated HIV viral load trajectories over 8 years following HAART initiation in the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study. The study included 157 HIV-infected men and 199 HIV-infected women who were antiretroviral naive and contributed 1311 and 1837 semiannual person-visits post-HAART, respectively. To account for within-subject correlation and the high proportion of left-censored viral loads, we used a segmental Bernoulli/lognormal random effects model.
resultsApproximately 3 months (0.30 years for men and 0.22 years for women) after HAART initiation, HIV viral loads were optimally suppressed (ie, with very low HIV RNA) for 44% (95% confidence interval = 39%-49%) of men and 43% (38%-47%) of women, whereas the other 56% of men and 57% of women had on average 2.1 (1.5-2.6) and 3.0 (2.7-3.2) log10 copies/mL, respectively.
conclusionAfter 8 years on HAART, 75% of men and 80% of women had optimal suppression, whereas the rest of the men and women had suboptimal suppression with a median HIV RNA of 3.1 and 3.7 log10 copies/mL, respectively.
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