ArticleNeurology2010
Contrasting gray and white matter changes in preclinical Huntington disease: an MRI study.
Article in Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Consistent neurodegeneration and its association with clinical progression in Huntington's disease: a coordinate-based meta-analysis.Neuro-degenerative diseases · 2013Pooled it
- Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.PloS one · 2015Trial
- Exploring Links between Brain Image-Derived Phenotypes and Accelerometer-Measured Physical Activity in the UK Biobank.bioRxiv : the preprint server for biology · 2026Article
- Differences in white matter detected by ex vivo 9.4 T MRI are associated with axonal changes in the R6/1 model of Huntington's disease.Neurobiology of disease · 2026Article
- Along-Tract Diffusion Alterations in the Dentato-Rubro-Thalamic Tract Correlate With Motor and Cognitive Decline in Huntington's Disease.Human brain mapping · 2025Article
- Mapping the glial transcriptome in Huntington's disease using snRNAseq: selective disruption of glial signatures across brain regions.Acta neuropathologica communications · 2024Article
- Article
- Classification of Huntington's Disease Stage with Features Derived from Structural and Diffusion-Weighted Imaging.Journal of personalized medicine · 2022Article
- Brain Alterations in Aged OVT73 Sheep Model of Huntington's Disease: An MRI Based Approach.Journal of Huntington's disease · 2022Article
- Oligodendroglial Heterogeneity in Neuropsychiatric Disease.Life (Basel, Switzerland) · 2021Review
- Diffusion imaging in Huntington's disease: comprehensive review.Journal of neurology, neurosurgery, and psychiatry · 2020Review
- A Critical Review of White Matter Changes in Huntington's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Review
- Impaired Remyelination in a Mouse Model of Huntington Disease.Molecular neurobiology · 2019Article
- Genetic load determines atrophy in hand cortico-striatal pathways in presymptomatic Huntington's disease.Human brain mapping · 2018Article
- Neurofilament light protein in blood predicts regional atrophy in Huntington disease.Neurology · 2018Article
- Altered Intracortical TFrontiers in neuroscience · 2018Article
- Neurofilament light protein in CSF and blood is associated with neurodegeneration and disease severity in Huntington's disease R6/2 mice.Scientific reports · 2017Article
- Mapping the order and pattern of brain structural MRI changes using change-point analysis in premanifest Huntington's disease.Human brain mapping · 2017Article
- Neuroimaging in Dementia.Seminars in neurology · 2017Review
- Intact sensory-motor network structure and function in far from onset premanifest Huntington's disease.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn Huntington disease (HD), substantial striatal atrophy precedes clinical motor symptoms. Accordingly, neuroprotection should prevent major cell loss before such symptoms arise. To evaluate neuroprotection, biomarkers such as MRI measures are needed. This requires first establishing the best imaging approach.
methodsUsing a cross-sectional design, we acquired T1-weighted and diffusion-weighted scans in 39 preclinical (pre-HD) individuals and 25 age-matched controls. T1-weighted scans were analyzed with gross whole-brain segmentation and voxel-based morphometry. Analysis of diffusion-weighted scans used skeleton-based tractography. For all imaging measures, we compared pre-HD and control groups and within the pre-HD group we examined correlations with estimated years to clinical onset.
resultsPre-HD individuals had lower gross gray matter (GM) and white matter (WM) volume. Voxel-wise analysis demonstrated local GM volume loss, most notably in regions consistent with basal ganglia-thalamocortical pathways. By contrast, pre-HD individuals showed widespread reductions in WM integrity, probably due to a loss of axonal barriers. Both GM and WM imaging measures correlated with estimated years to onset.
conclusionsUsing automated, observer-independent methods, we found that GM loss in pre-HD was regionally specific, while WM deterioration was much more general and probably the result of demyelination rather then axonal degeneration. These findings provide important information about the nature, relative staging, and topographic specificity of brain changes in pre-HD and suggest that combining GM and WM imaging may be the best biomarker approach. The empirically derived group difference images from this study are provided as regions-of-interest masks for improved sensitivity in future longitudinal studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.