ArticleNeurology2010
A visual migraine aura locus maps to 9q21-q22.
Article in Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Molecular typing of familial temporal lobe epilepsy.World journal of psychiatry · 2022Review
- Genetic Interaction ofPharmacogenomics and personalized medicine · 2021Article
- Family studies to find rare high risk variants in migraine.The journal of headache and pain · 2017Review
- Chromosome loci vary by juvenile myoclonic epilepsy subsyndromes: linkage and haplotype analysis applied to epilepsy and EEG 3.5-6.0 Hz polyspike waves.Molecular genetics & genomic medicine · 2016Article
- Migraine genetics: current findings and future lines of research.Neurogenetics · 2015Article
- PSEUDOMARKER 2.0: efficient computation of likelihoods using NOMAD.BMC bioinformatics · 2014Article
- Migralepsy: a borderland of wavy lines.Current neurology and neuroscience reports · 2014Review
- Comorbidity of Migraine.Noro psikiyatri arsivi · 2013Review
- New directions in migraine.BMC medicine · 2011Review
- Identification of molecular genetic factors that influence migraine.Molecular genetics and genomics : MGG · 2011Review
- Comorbidities of migraine.Frontiers in neurology · 2010Article
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveTo identify susceptibility loci for visual migraine aura in migraine families primarily affected with scintillating scotoma type of aura.
methodsWe included Finnish migraine families with at least 2 affected family members with scintillating scotoma as defined by the International Criteria for Headache Disorders-II. A total of 36 multigenerational families containing 351 individuals were included, 185 of whom have visual aura and 159 have scintillating scotoma. Parametric and nonparametric linkage analyses were performed with 378 microsatellite markers. The most promising linkage loci found were fine-mapped with additional microsatellite markers.
resultsA novel locus on chromosome 9q22-q31 for migraine aura was identified (HLOD = 4.7 at 104 cM). Fine-mapping identified a shared haplotype segment of 12 cM (9.8 Mb) on 9q21-q22 among the aura affected. Four other loci showed linkage to aura: a locus on 12p13 showed significant evidence of linkage, and suggestive evidence of linkage was detected to loci on chromosomes 5q13, 6q25, and 13q14.
conclusionsA novel visual migraine aura locus has been mapped to chromosome 9q21-q22. Interestingly, this region has previously been linked to occipitotemporal lobe epilepsy with prominent visual symptoms. Our finding further supports a shared genetic background in migraine and epilepsy and suggests that susceptibility variant(s) to visual aura for both of these traits are located in the 9q21-q22 locus.
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