ArticleProceedings of the National Academy of Sciences of the United States of America2010
Conservation of recombination hotspots in yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Article
- The recombination landscape of introgression in yeast.PLoS genetics · 2025Article
- Multiple losses of aKRAB from PRDM9 coincide with a teleost-specific intron size distribution.BMC biology · 2024Article
- Multiple independent losses of crossover interference during yeast evolutionary history.PLoS genetics · 2024Article
- The recombination landscape of introgression in yeast.bioRxiv : the preprint server for biology · 2024Article
- Understanding the Genetic Basis of Variation in Meiotic Recombination: Past, Present, and Future.Molecular biology and evolution · 2024Review
- Approximate Bayesian computational methods to estimate the strength of divergent selection in population genomics models.Journal of Computational Mathematics and Data Science · 2024Article
- Fine-Scale Map Reveals Highly Variable Recombination Rates Associated with Genomic Features in the Eurasian Blackcap.Genome biology and evolution · 2024Article
- Rapid Evolution of the Fine-scale Recombination Landscape in Wild House Mouse (Mus musculus) Populations.Molecular biology and evolution · 2023Article
- Lessons from the meiotic recombination landscape of the ZMM deficient budding yeast Lachancea waltii.PLoS genetics · 2023Article
- Adaptive Control of the Meiotic Recombination Landscape by DNA Site-dependent Hotspots With Implications for Evolution.Frontiers in genetics · 2022Article
- Evolution of Recombination Landscapes in Diverging Populations of Bread Wheat.Genome biology and evolution · 2021Article
- Recombination Rate Variation and Infrequent Sex Influence Genetic Diversity in Chlamydomonas reinhardtii.Genome biology and evolution · 2020Article
- Divergent Fine-Scale Recombination Landscapes between a Freshwater and Marine Population of Threespine Stickleback Fish.Genome biology and evolution · 2019Article
- Historical Meiotic Crossover Hotspots Fueled Patterns of Evolutionary Divergence in Rice.The Plant cell · 2019Article
- Evolution of the Yeast Recombination Landscape.Molecular biology and evolution · 2019Article
- Accurate annotation of accessible chromatin in mouse and human primordial germ cells.Cell research · 2018Article
- Quantifying how constraints limit the diversity of viable routes to adaptation.PLoS genetics · 2018Article
- Fine-Scale Recombination Maps of Fungal Plant Pathogens Reveal Dynamic Recombination Landscapes and Intragenic Hotspots.Genetics · 2018Article
- Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias.Nature ecology & evolution · 2018Article
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Authors and funding
3 authors.
Funding
Abstract
Meiotic recombination does not occur randomly along a chromosome, but instead tends to be concentrated in small regions, known as "recombination hotspots." Recombination hotspots are thought to be short-lived in evolutionary time due to their self-destructive nature, as gene conversion favors recombination-suppressing alleles over recombination-promoting alleles during double-strand repair. Consistent with this expectation, hotspots in humans are highly dynamic, with little correspondence in location between humans and chimpanzees. Here, we identify recombination hotspots in two lineages of the yeast Saccharomyces paradoxus, and compare their locations to those found previously in Saccharomyces cerevisiae. Surprisingly, we find considerable overlap between the two species, despite the fact that they are at least 10 times more divergent than humans and chimpanzees. We attribute this unexpected result to the low frequency of sex and outcrossing in these yeasts, acting to reduce the population genetic effect of biased gene conversion. Traces from two other signatures of recombination, namely high mutagenicity and GC-biased gene conversion, are consistent with this interpretation. Thus, recombination hotspots are not inevitably short-lived, but rather their persistence through evolutionary time will be determined by the frequency of outcrossing events in the life cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.