ArticlePhysiology & behavior2010
Decreased food intake following overfeeding involves leptin-dependent and leptin-independent mechanisms.
Article in Physiology & behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice.The Journal of physiology · 2025Article
- Neuroanatomical dissection of the MC3R circuitry regulating energy rheostasis.bioRxiv : the preprint server for biology · 2024Article
- Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R.Nature communications · 2024Article
- Models of body weight and fatness regulation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Highly recruited brown adipose tissue does not in itself protect against obesity.Molecular metabolism · 2023Article
- Physiological protection against weight gain: evidence from overfeeding studies and future directions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- The physiology of experimental overfeeding in animals.Molecular metabolism · 2022Review
- Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity.Nature metabolism · 2022Article
- Post-oral sensing of fat increases food intake and attenuates body weight defense.Cell reports · 2021Article
- Central nervous system regulation of organismal energy and glucose homeostasis.Nature metabolism · 2021Review
- The obesity epidemic in the face of homeostatic body weight regulation: What went wrong and how can it be fixed?Physiology & behavior · 2020Review
- The unidentified hormonal defense against weight gain.PLoS biology · 2020Article
- Recent advances in understanding the role of leptin in energy homeostasis.F1000Research · 2020Review
- Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis.Gut microbes · 2018Article
- Article
- Does gastric bypass surgery change body weight set point?International journal of obesity supplements · 2016Review
- The Macronutrients, Appetite, and Energy Intake.Annual review of nutrition · 2016Review
- Costs of Foraging Predispose Animals to Obesity-Related Mortality when Food Is Constantly Abundant.PloS one · 2015Article
- A missing link in body weight homeostasis: the catabolic signal of the overfed state.Cell metabolism · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
After a period of forced overfeeding, many individuals actively compensate for this weight gain by reducing food intake and maintaining this state of hypophagia well into the post-overfeeding period. Our central goal is to define the mechanism underlying this adaptive reduction in food intake. When male Long Evans rats were implanted with indwelling gastric cannula and overfed a liquid low-fat (10% fat) diet for 17 days, overfed rats exhibited increased weight gain (P<0.01) but decreased food intake, and this hypophagia persisted for 4-6 days post-overfeeding (P<0.05). Leptin levels were increased 8-fold by overfeeding (P<0.01), yet returned to baseline within 2 days post-overfeeding, despite the persistent hypophagia. Energy expenditure and oxygen consumption (VO2) were increased on the first day post-overfeeding (P<0.05), but subsequently normalized prior to the normalization of food intake. Lastly, in leptin receptor deficient Obese Zucker (fa/fa) rats, overfeeding produced a significant decrease in food intake during active overfeeding. However, food intake returned to near baseline levels within one day post-overfeeding. Contrastingly, food intake remained suppressed in lean controls for 6 days post-overfeeding. Thus intact leptin signaling is not required for the decrease in food intake that occurs during overfeeding, but the ability to maintain this hypophagia is substantially impaired in the absence of leptin signaling. In addition, this post-overfeeding leptin effect appears to occur despite the fact that leptin levels normalize relatively rapidly post-overfeeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.