ArticleMolecular cell2010
A competitive transcription factor binding mechanism determines the timing of late cell cycle-dependent gene expression.
Article in Molecular cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 66 citations in OpenAlex.
- Combinatorial transcription factor binding encodes cis-regulatory wiring of mouse forebrain GABAergic neurogenesis.Developmental cell · 2025Article
- Comprehensive analysis of the REST transcription factor regulatory networks in IDH mutant and IDH wild-type glioma cell lines and tumors.Acta neuropathologica communications · 2024Article
- A map of cis-regulatory modules and constituent transcription factor binding sites in 80% of the mouse genome.BMC genomics · 2022Article
- Identification of DNA motifs that regulate DNA methylation.Nucleic acids research · 2019Article
- A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe.BMC genomics · 2019Article
- Evolutionary Potential of Cis-Regulatory Mutations to Cause Rapid Changes in Transcription Factor Binding.Genome biology and evolution · 2019Article
- Relatively frequent switching of transcription start sites during cerebellar development.BMC genomics · 2017Article
- Transcriptional and post-transcriptional regulation of Cdc20 during the spindle assembly checkpoint in S. cerevisiae.Cellular signalling · 2017Article
- Article
- Cell cycle regulated transcription: from yeast to cancer.F1000Research · 2016Review
- STUbL-mediated degradation of the transcription factor MATα2 requires degradation elements that coincide with corepressor binding sites.Molecular biology of the cell · 2015Article
- Functional Analysis and Characterization of Differential Coexpression Networks.Scientific reports · 2015Article
- A new transcription factor for mitosis: in Schizosaccharomyces pombe, the RFX transcription factor Sak1 works with forkhead factors to regulate mitotic expression.Nucleic acids research · 2015Article
- Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression.The EMBO journal · 2014Article
- Rad53 downregulates mitotic gene transcription by inhibiting the transcriptional activator Ndd1.Molecular and cellular biology · 2014Article
- Periodic mRNA synthesis and degradation co-operate during cell cycle gene expression.Molecular systems biology · 2014Article
- Review
- The roles of two transcription factors, ABI4 and CBFA, in ABA and plastid signalling and stress responses.Plant molecular biology · 2013Article
- Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.Pigment cell & melanoma research · 2013Article
- Bck2 acts through the MADS box protein Mcm1 to activate cell-cycle-regulated genes in budding yeast.PLoS genetics · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Transcriptional control is exerted by the antagonistic activities of activator and repressor proteins. In Saccharomyces cerevisiae, transcription factor complexes containing the MADS box protein Mcm1p are key regulators of cell cycle-dependent transcription at both the G2/M and M/G1 transitions. The homeodomain repressor protein Yox1p acts in a complex with Mcm1p to control the timing of gene expression. Here, we show that Yox1p interacts with Mcm1p through a motif located N terminally to its homeodomain. Yox1p functions as a transcriptional repressor by competing with the forkhead transcription activator protein Fkh2p for binding to Mcm1p through protein-protein interactions at promoters of a subset of Mcm1p-regulated genes. Importantly, this competition is not through binding the same DNA site that is commonly observed. Thus, this study describes a different mechanism for determining the timing of cell cycle-dependent gene expression that involves competition between short peptide motifs in repressor and activator proteins for interaction with a common binding partner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.