ArticleGenome biology2010
The developmental expression dynamics of Drosophila melanogaster transcription factors.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
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- MAGE genes encoding for embryonic development in cattle is mainly regulated by zinc finger transcription factor family and slightly by CpG Islands.BMC genomic data · 2022Article
- Automated generation of context-specific gene regulatory networks with a weighted approach inInterface focus · 2021Article
- Dynamics of Gene Co-expression Networks in Time-Series Data: A Case Study inFrontiers in genetics · 2020Article
- A Comprehensive Drosophila melanogaster Transcription Factor Interactome.Cell reports · 2019Article
- Stability-driven nonnegative matrix factorization to interpret spatial gene expression and build local gene networks.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Regulation of transcription factors on sexual dimorphism of fig wasps.Scientific reports · 2015Article
- Transcription factor networks in Drosophila melanogaster.Cell reports · 2014Article
- Spatial expression of transcription factors in Drosophila embryonic organ development.Genome biology · 2013Article
- Article
- A comparative analysis of transcription factor expression during metazoan embryonic development.PloS one · 2013Article
- Spatiotemporal network motif reveals the biological traits of developmental gene regulatory networks in Drosophila melanogaster.BMC systems biology · 2012Article
- Dynamic reprogramming of chromatin accessibility during Drosophila embryo development.Genome biology · 2011Article
- Mapping the complexity of transcription control in higher eukaryotes.Genome biology · 2010Article
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2 authors at 1 institution in 1 country.
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Abstract
backgroundSite-specific transcription factors (TFs) are coordinators of developmental and physiological gene expression programs. Their binding to cis-regulatory modules of target genes mediates the precise cell- and context-specific activation and repression of genes. The expression of TFs should therefore reflect the core expression program of each cell.
resultsWe studied the expression dynamics of about 750 TFs using the available genomics resources in Drosophila melanogaster. We find that 95% of these TFs are expressed at some point during embryonic development, with a peak roughly between 10 and 12 hours after egg laying, the core stages of organogenesis. We address the differential utilization of DNA-binding domains in different developmental programs systematically in a spatio-temporal context, and show that the zinc finger class of TFs is predominantly early expressed, while Homeobox TFs exhibit later expression in embryogenesis.
conclusionsPrevious work, dissecting cis-regulatory modules during Drosophila development, suggests that TFs are deployed in groups acting in a cooperative manner. In contrast, we find that there is rapid exchange of co-expressed partners amongst the fly TFs, at rates similar to the genome-wide dynamics of co-expression clusters. This suggests there may also be a high level of combinatorial complexity of TFs at cis-regulatory modules.
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