ArticleEpilepsia2010
Brain development in children with new onset epilepsy: a prospective controlled cohort investigation.
Article in Epilepsia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Impact of chronic kidney disease stage on seizure frequency and severity in pediatric epilepsy patients.BMC nephrology · 2026Article
- Modelling risk factors for depressive symptoms in seizure disorders.Therapeutic advances in neurological disorders · 2026Article
- Article
- The relationship between neuromagnetic networks and cognitive impairment in self-limited epilepsy with centrotemporal spikes.Epilepsia open · 2025Article
- Transient Ipsilateral Hemineglect Following Brain Laser Ablation in Patient with Focal Cortical Dysplasia.Neurology international · 2024Article
- Stress phenotypes in epilepsy: impact on cognitive functioning and quality of life.Frontiers in psychology · 2023Article
- Article
- Application Value of Serum Metabolic Markers for Cognitive Prediction in Elderly Epilepsy.Neuropsychiatric disease and treatment · 2022Article
- Evaluation of cortical thickness and brain volume on 3 Tesla magnetic resonance imaging in children with frontal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Attention deficit hyperactivity disorder (ADHD) in children with epilepsy.Irish journal of medical science · 2020Article
- Premature white matter aging in patients with right mesial temporal lobe epilepsy: A machine learning approach based on diffusion MRI data.NeuroImage. Clinical · 2019Article
- Functional and Structural Network Disorganizations in Typical Epilepsy With Centro-Temporal Spikes and Impact on Cognitive Neurodevelopment.Frontiers in neurology · 2019Review
- Role of DNA Methylation and Adenosine in Ketogenic Diet for Pharmacoresistant Epilepsy: Focus on Epileptogenesis and Associated Comorbidities.Frontiers in neurology · 2019Review
- Intraindividual variability in attentional vigilance in children with epilepsy.Epilepsy & behavior : E&B · 2018Article
- Article
- Cognitive and neurodevelopmental comorbidities in paediatric epilepsy.Nature reviews. Neurology · 2016Review
- Structural Abnormalities in Childhood Absence Epilepsy: Voxel-Based Analysis Using Diffusion Tensor Imaging.Frontiers in human neuroscience · 2016Article
- Quantitative magnetic resonance imaging evidence for altered structural remodeling of the temporal lobe in West syndrome.Epilepsia · 2015Observational
- Factors affecting reorganisation of memory encoding networks in temporal lobe epilepsy.Epilepsy research · 2015Article
- Gray and White Matter Volumes and Cognitive Dysfunction in Drug-Naïve Newly Diagnosed Pediatric Epilepsy.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeTo characterize prospective neurodevelopmental changes in brain structure in children with new and recent-onset epilepsy compared to healthy controls.
methodsThirty-four healthy controls (mean age 12.9 years) and 38 children with new/recent-onset idiopathic epilepsy (mean age 12.9 years) underwent 1.5 T magnetic resonance imaging (MRI) at baseline and 2 years later. Prospective changes in total cerebral and lobar gray and white matter volumes were compared within and between groups.
resultsProspective changes in gray matter volume were comparable for the epilepsy and control groups, with significant (p < 0.0001) reduction in total cerebral gray matter, due primarily to significant (p < 0.001) reductions in frontal and parietal gray matter. Prospective white matter volume changes differed between groups. Controls exhibited a significant (p = 0.0012) increase in total cerebral white matter volume due to significant (p < 0.001) volume increases in the frontal, parietal, and temporal lobes. In contrast, the epilepsy group exhibited nonsignificant white matter volume change in the total cerebrum (p = 0.51) as well as across all lobes (all p's > 0.06). The group by white matter volume change interactions were significant for total cerebrum (p = 0.04) and frontal lobe (p = 0.04). DISCUSSION: Children with new and recent-onset epilepsy exhibit an altered pattern of brain development characterized by delayed age-appropriate increase in white matter volume. These findings may affect cognitive development through reduced brain connectivity and may also be related to the impairments in executive function commonly reported in this population.
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