ArticleEnvironmental science & technology2010
Serum PCB concentrations and cochlear function in 12-year-old children.
Article in Environmental science & technology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of ambient air pollution, fresh fruit and vegetable intakes as well as maternal psychosocial stress on the outcome of newborn otoacoustic emission hearing screening.BMC pediatrics · 2022Article
- Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish.Communications biology · 2021Article
- PCB exposure and potential future cancer incidence in Slovak children: an assessment from molecular finger printing by Ingenuity Pathway Analysis (IPA®) derived from experimental and epidemiological investigations.Environmental science and pollution research international · 2018Article
- Developmental exposure to an environmental PCB mixture delays the propagation of electrical kindling from the amygdala.Neurotoxicology · 2017Article
- PCB exposure and cochlear function at age 6 years.Environmental research · 2016Article
- DPOAEs in infants developmentally exposed to PCBs show two differently time spaced exposure sensitive windows.Chemosphere · 2016Article
- Developmental exposure to PCBs alters the activation of the auditory cortex in response to GABANeurotoxicology · 2016Article
- Prenatal low dosage dioxin (TCDD) exposure impairs cochlear function resulting in auditory neuropathy.Hearing research · 2016Article
- Environmental exposure to organochlorine pesticides and deficits in cochlear status in children.Environmental science and pollution research international · 2015Article
- Transcriptional profiling and biological pathway analysis of human equivalence PCB exposure in vitro: indicator of disease and disorder development in humans.Environmental research · 2015Article
- The 12th International HCH and Pesticides Forum in Kiev/Ukraine.Environmental science and pollution research international · 2015Article
- Developmental PCB exposure increases susceptibility to audiogenic seizures in adulthood.Neurotoxicology · 2015Article
- PCBs and impaired cochlear function in children: comparing pre- and postnatal exposures.Environmental health perspectives · 2014Article
- Prenatal and postnatal serum PCB concentrations and cochlear function in children at 45 months of age.Environmental health perspectives · 2014Article
- Biomarkers linking PCB exposure and obesity.Current pharmaceutical biotechnology · 2014Review
- Differential gene expression and a functional analysis of PCB-exposed children: understanding disease and disorder development.Environment international · 2012Article
- Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: correlations between gene expression and disease risk.Environment international · 2012Article
- Effects of developmental exposure to polychlorinated biphenyls and/or polybrominated diphenyl ethers on cochlear function.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Experimental evidence from animals indicates that exposure to polychlorinated biphenyls (PCBs) causes deterioration of the outer hair cells (OHCs) of the cochlea. To test this hypothesis in humans, we measured serum PCB concentrations in 574 12-year-old children residing in three districts in the Slovak Republic using high-resolution gas chromatography with microelectron capture detection. As a marker of cochlear status, we measured transient evoked (TE) and distortion product (DP) otoacoustic emissions (OAEs), and assessed the cross-sectional association between serum PCBs and OAEs. Median total PCB concentrations were 352.8, 150.5, and 134.9 ng/g lipid in Michalovce, Svidnik, and Bratislava, respectively. In multivariate regression models where otoacoustic measures were modeled as a function of log (base 10) PCB concentrations with adjustment for gender, age, and site of examination, dioxin-like PCBs, nondioxin-like PCBs and a PCB grouping targeting upregulation of hepatic uridine 5'-diphospho-glucuronosyltransferase were significantly associated with lower TEOAE powers at 1000 and 1500 Hz. At 1500 Hz, we observed a strong association with sum of PCBs and DL-PCBs, in the left ear only. The DPOAEs at 1000 Hz were associated with all four PCB groupings. The results of this study show that PCBs may affect the OHCs of the cochlea, a result consistent with findings from animal studies published to date.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.