ArticlePflugers Archiv : European journal of physiology2010
Oxygen sensing and conducted vasomotor responses in mouse cremaster arterioles in situ.
Article in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Effects of hyperoxia on vascular tone in animal models: systematic review and meta-analysis.Critical care (London, England) · 2018Pooled it
- Development of thin-film micro-outlets for spatially constraining local POFrontiers in physiology · 2025Article
- Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Inhibition of NaThe Journal of physiology · 2018Article
- Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion.Microcirculation (New York, N.Y. : 1994) · 2018Article
- Conducted dilatation to ATP and KActa physiologica (Oxford, England) · 2017Article
- Article
- Arteriolar oxygen reactivity: where is the sensor and what is the mechanism of action?The Journal of physiology · 2016Review
- Functional sympatholysis and sympathetic escape in a theoretical model for blood flow regulation.Frontiers in physiology · 2014Article
- Capillary recruitment in a theoretical model for blood flow regulation in heterogeneous microvessel networks.Physiological reports · 2013Article
- Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo.BMC physiology · 2013Article
- Spontaneous oscillations in a model for active control of microvessel diameters.Mathematical medicine and biology : a journal of the IMA · 2012Article
- Theoretical comparison of wall-derived and erythrocyte-derived mechanisms for metabolic flow regulation in heterogeneous microvascular networks.American journal of physiology. Heart and circulatory physiology · 2012Article
- Modeling Ca2+ signaling in the microcirculation: intercellular communication and vasoreactivity.Critical reviews in biomedical engineering · 2011Review
- Nitric oxide signaling in the microcirculation.Critical reviews in biomedical engineering · 2011Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examines mechanisms by which changes in tissue oxygen tension elicit vasomotor responses and whether localized changes in oxygen tension initiates conducted vasomotor responses in mouse cremaster arterioles. Intravital microscopy was used to visualize the mouse cremaster microcirculation. The cremaster was superfused with Krebs' solution with different oxygen tensions, and a gas exchange chamber was used to induce localized changes in oxygen tension. In arterioles where red blood cells were removed by buffer perfusion, arterioles responded with same magnitudes of vasodilatation (DeltaD = 16.0 +/- 4.9 microm) when changing from high (PO(2) = 242.5 +/- 13.3 mm Hg) to low (PO(2) = 22.5 +/- 4.8 mm Hg) oxygen tension as seen in the intact cremaster circulation (DeltaD = 18.7 +/- 1.0 microm). Blockade of NO synthases by L: -NAME and adenosine receptors by DPCPX had no effects on vasomotor responses to low or high oxygen. Induction of localized low (PO(2) = 23.3 +/- 5.7 mmHg) or high (PO(2) = 300.0 +/- 25.7 mm Hg) oxygen tension caused vasodilatation or -constriction locally and at a site 1,000 microm upstream (distantly). Glibenclamide blocker of ATP-sensitive K(+) channels inhibited vasodilatation and -constriction to low (PO(2) = 16.0 +/- 6.4 mm Hg) and high (PO(2) = 337.4 +/- 12.8 mm Hg) oxygen tension. 1) ATP-sensitive K(+) channels seem to mediate, at least in part, vasodilatation and vasoconstriction to low and high oxygen tension; 2) Red blood cells are not necessary for inducing vasodilatation and vasoconstriction to low or high oxygen tension; 3) localized changes in the oxygen tension cause vasomotor responses, which are conducted upstream along arterioles in mouse cremaster microcirculation.
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