ReviewNeuropsychology review2010
Parkinson's disease as a disconnection syndrome.
Review in Neuropsychology review, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Global Alterations of Whole Brain Structural Connectome in Parkinson's Disease: A Meta-analysis.Neuropsychology review · 2023Pooled it
- Altered white matter microarchitecture in Parkinson's disease: a voxel-based meta-analysis of diffusion tensor imaging studies.Frontiers of medicine · 2021Pooled it
- Visuospatial Attention to Single and Multiple Objects Is Independently Impaired in Parkinson's Disease.PloS one · 2016Trial
- Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson's Disease.BioMed research international · 2015Trial
- Structural Connectome Alterations in Alternating Hemiplegia of Childhood.Brain topography · 2026Article
- Local and global microstructural and functional thalamomotor connectivity alterations in Parkinson's disease following motor learning.NPJ Parkinson's disease · 2026Article
- Novel psychophysical line bisection task using brief stimulus presentation reveals no horizontal bias in left-onset parkinson's disease.Scientific reports · 2026Article
- Multimodal brain network topology and enhanced computer-aided diagnosis in Parkinson's Disease: a systematic review and meta-analysis.NPJ digital medicine · 2026Article
- Possible Implications of Managing Alexithymia on Quality of Life in Parkinson's Disease: A Systematic Review.Parkinson's disease · 2024Review
- Normalization effect of levodopa on hierarchical brain function in Parkinson's disease.Network neuroscience (Cambridge, Mass.) · 2022Article
- Brain functional specialization and cooperation in Parkinson's disease.Brain imaging and behavior · 2022Article
- Altered microstructural properties of superficial white matter in patients with Parkinson's disease.Brain imaging and behavior · 2022Article
- Alteration in Asymmetry of White Matter Network of Parkinson's Disease.Contrast media & molecular imaging · 2022Article
- Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Structural network topology and microstructural alterations of the anterior insula associate with cognitive and affective impairment in Parkinson's disease.Scientific reports · 2021Article
- Functional connectivity of spoken language processing in early-stage Parkinson's disease: An MEG study.NeuroImage. Clinical · 2021Article
- The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson's Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline.Journal of Parkinson's disease · 2021Review
- Gender Differences and Quality of Life in Parkinson's Disease.International journal of environmental research and public health · 2020Review
- Unique white matter structural connectivity in early-stage drug-naive Parkinson disease.Neurology · 2020Article
- Machine-learning identifies Parkinson's disease patients based on resting-state between-network functional connectivity.The British journal of radiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Parkinson's disease (PD) is a major neurodegenerative disorder that is usually considered in terms of midbrain and basal ganglia dysfunction. Regarding PD instead as a disconnection syndrome may prove beneficial to understanding aspects of cognition, perception, and other neuropsychological domains in the disease. PD is usually of unilateral onset, providing evidence of intrahemispheric dissociations and an imbalance in the usual relative strengths of the right and left hemispheres. Hence, in order to appreciate the neuropsychology of PD, it is important to apply to this disease our understanding of hemispheric lateralization effects and within-hemisphere circuitry from brainstem to higher-order association cortex. The focus of this review is on the relevance of PD-related disconnections among subcortical and cortical structures to cognition, perception, emotion, and associated brainstem-based domains such as sleep and mood disturbance. Besides providing information on disease characteristics, regarding PD as a disconnection syndrome allows us to more completely understand normal brain-behavior relations in general.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.