ArticleBreast cancer research and treatment2010
BRCA1/2 test results impact risk management attitudes, intentions, and uptake.
Article in Breast cancer research and treatment, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Trial
- Attitude towards hereditary cancer risk management among women with cancer in Taiwan.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Predictors of risk-reducing surgery intentions following genetic counseling for hereditary breast and ovarian cancer.Translational behavioral medicine · 2020Article
- Precision prophylaxis: Identifying the optimal timing for risk-reducing salpingo-oophorectomy based on type of BRCA1 and BRCA2 cluster region mutations.Gynecologic oncology · 2020Article
- Psychosocial Effects of Multigene Panel Testing in the Context of Cancer Genomics.The Hastings Center report · 2019Article
- An iPhone Application Intervention to Promote Surveillance Among Women with a BRCA Mutation: Pre-intervention Data.Journal of genetic counseling · 2018Article
- Randomized Noninferiority Trial of Telephone vs In-Person Genetic Counseling for Hereditary Breast and Ovarian Cancer: A 12-Month Follow-Up.JNCI cancer spectrum · 2017Article
- Adherence to Recommended Risk Management among Unaffected Women with a BRCA Mutation.Journal of genetic counseling · 2017Article
- Impact of genomic testing and patient-reported outcomes on receipt of adjuvant chemotherapy.Breast cancer research and treatment · 2016Article
- The impact ofGenes & nutrition · 2016Article
- Genetic counseling content: How does it impact health behavior?Journal of behavioral medicine · 2015Article
- Intentions for risk-reducing surgery among high-risk women referred for BRCA1/BRCA2 genetic counseling.Psycho-oncology · 2015Article
- Conveying genomic recurrence risk estimates to patients with early-stage breast cancer: oncologist perspectives.Psycho-oncology · 2013Article
- Comparison of the screening practices of unaffected noncarriers under 40 and between 40 and 49 in BRCA1/2 families.Journal of genetic counseling · 2013Article
- Intentions for bilateral mastectomy among newly diagnosed breast cancer patients.Journal of surgical oncology · 2013Article
- Impact of genetic risk assessment on nutrition-related lifestyle behaviours.The Proceedings of the Nutrition Society · 2013Review
- Challenges of genetic testing in adolescents with cardiac arrhythmia syndromes.Journal of medical ethics · 2012Article
- Beliefs about Genetically Targeted Care in African Americans.Journal of the National Medical AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Women who receive positive or uninformative BRCA1/2 test results face a number of decisions about how to manage their cancer risk. The purpose of this study was to prospectively examine the effect of receiving a positive versus uninformative BRCA1/2 genetic test result on the perceived pros and cons of risk-reducing mastectomy (RRM) and risk-reducing oophorectomy (RRO) and breast cancer screening. We further examined how perceived pros and cons of surgery predict intention for and uptake of surgery. 308 women (146 positive, 162 uninformative) were included in RRM and breast cancer screening analyses. 276 women were included in RRO analyses. Participants completed questionnaires at pre-disclosure baseline and 1-, 6-, and 12-months post-disclosure. We used linear multiple regression to assess whether test result contributed to change in pros and cons and logistic regression to predict intentions and surgery uptake. Receipt of a positive BRCA1/2 test result predicted stronger pros for RRM and RRO (P < 0.001), but not perceived cons of RRM and RRO. Pros of surgery predicted RRM and RRO intentions in carriers and RRO intentions in uninformatives. Cons predicted RRM intentions in carriers. Pros and cons predicted carriers' RRO uptake in the year after testing (P < 0.001). Receipt of BRCA1/2 mutation test results impacts how carriers see the positive aspects of RRO and RRM and their surgical intentions. Both the positive and negative aspects predict uptake of surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.