Evidence map›Paper›PMID 20383545›Full record

Trial reportClinical oral investigations2011

Treatment of post-orthodontic white spot lesions with casein phosphopeptide-stabilised amorphous calcium phosphate.

Ann Bröchner, Carsten Christensen, Bjarne Kristensen, Sofia Tranæus, Lena Karlsson, Liselotte Sonnesen, Svante Twetman

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05733676 (Comparison of MI Paste Plus and Resin Infiltration in Improvement of White Spot Lesions Following Fixed Orthodontic Treatment), which is not on this map. Cited by 49 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 7 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05733676 narecruitingnot on this mapstarted 2023, after this paper: background citation

Comparison of MI Paste Plus and Resin Infiltration in Improvement of White Spot Lesions Following Fixed Orthodontic Treatment: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of AlbertaRan2023 to 2028Enrolled62ConditionsWhite Spot Lesions, Orthodontic Appliance Complication, Caries Arrested, Smooth Surface CariesArmsResin infiltration, Casein Phosphopeptide (CPP) - Amorphous Calcium Phosphate (ACP) - Fluoride
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 7 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. [Remineralization effect of casein phosphopeptide-amorphous calcium phosphate for enamel demineralization: a system review].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017
    Pooled it
  7. Pooled it
  8. Trial
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  14. Effectiveness of MI Paste Plus and PreviDent fluoride varnish for treatment of white spot lesions: a randomized controlled trial.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2013
    Trial
  15. Trial
  16. Review
  17. Article
  18. Article
  19. Impact of adhesive layer addition on the optical properties of remineralized white spot lesions.Journal of dental research, dental clinics, dental prospects · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Ann BröchnerDepartment of Orthodontics, Odense Central Clinic, Tandplejen Grønløkkevej 30, DK-5000 Odense C, Denmark.
Carsten Christensen
Bjarne Kristensen
Sofia Tranæus
Lena Karlsson
Liselotte Sonnesen
Svante Twetman
Odense University Hospital · DKKarolinska Institutet · SECounty Hospital · GBUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to investigate the effect of topical applications of 10% casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on white spot lesions (WSL) detected after treatment with fixed orthodontic appliances. Sixty healthy adolescents with ≥1 clinically visible WSL at debonding were recruited and randomly allocated to a randomised controlled trial with two parallel groups. The intervention group was instructed to topically apply a CPP-ACP -containing agent (Tooth Mousse, GC Europe) once daily and the subjects of the control group brushed their teeth with standard fluoride toothpaste. The intervention period was 4 weeks and the endpoints were quantitative light-induced fluorescence (QLF) on buccal surfaces of the upper incisors, cuspids and first premolars and visual scoring from digital photos. The attrition rate was 15%, mostly due to technical errors, and 327 lesions were included in the final evaluation. A statistically significant (p < 0.05) regression of the WSL was disclosed in both study groups compared to baseline, but there was no difference between the groups. The mean area of the lesions decreased by 58% in the CPP-ACP group and 26% in the fluoride group (p = 0.06). The QLF findings were largely reflected by the clinical scores. No side effects were reported. Topical treatment of white spot lesions after debonding of orthodontic appliances with a casein phosphopeptide-stabilised amorphous calcium phosphate agent resulted in significantly reduced fluorescence and a reduced area of the lesions after 4 weeks as assessed by QLF. The improvement was however not superior to the "natural" regression following daily use of fluoride toothpaste.

Indexed as

AdolescentAnalysis of VarianceCariostatic AgentsCaseinsChi-Square DistributionDental CariesDental Caries Activity TestsFemaleFluorescenceHumansLightMaleOrthodontic BracketsProspective StudiesRadiography, Dental, DigitalReproducibility of ResultsCariostatic Agentscasein phosphopeptide-amorphous calcium phosphate nanocomplexCaseins

Identifiers

PMID20383545
OpenAlexW2003079684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.