ArticleArchives of virology2010
Three amino acid changes in PB1-F2 of highly pathogenic H5N1 avian influenza virus affect pathogenicity in mallard ducks.
Article in Archives of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- Dominant HPAIV H5N1 genotypes of Germany 2021/2022 are linked to high virulence in Pekin ducklings.Npj viruses · 2024Article
- Genomic characterization of equine influenza A subtype H3N8 viruses by long read sequencing and functional analyses of the PB1-F2 virulence factor of A/equine/Paris/1/2018.Veterinary research · 2024Article
- Reported human infections of H9N2 avian influenza virus in China in 2021.Frontiers in public health · 2023Article
- Influenza PB1-F2 Inhibits Avian MAVS Signaling.Viruses · 2020Article
- Inventory of molecular markers affecting biological characteristics of avian influenza A viruses.Virus genes · 2019Review
- Article
- Duck innate immune responses to high and low pathogenicity H5 avian influenza viruses.Veterinary microbiology · 2019Article
- Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006-2016).Emerging microbes & infections · 2018Article
- IFN and cytokine responses in ducks to genetically similar H5N1 influenza A viruses of varying pathogenicity.The Journal of general virology · 2018Article
- Apoptotic and Early Innate Immune Responses to PB1-F2 Protein of Influenza A Viruses Belonging to Different Subtypes in Human Lung Epithelial A549 Cells.Advances in virology · 2018Article
- Evolution and Virulence of Influenza A Virus Protein PB1-F2.International journal of molecular sciences · 2017Review
- A complete map of potential pathogenicity markers of avian influenza virus subtype H5 predicted from 11 expressed proteins.BMC microbiology · 2015Article
- Crucial role of PA in virus life cycle and host adaptation of influenza A virus.Medical microbiology and immunology · 2015Review
- Genetic Characterization of H1N1 and H1N2 Influenza A Viruses Circulating in Ontario Pigs in 2012.PloS one · 2015Article
- The ubiquitination of the influenza A virus PB1-F2 protein is crucial for its biological function.PloS one · 2015Article
- Molecular characterization of H3N2 influenza A viruses isolated from Ontario swine in 2011 and 2012.Virology journal · 2014Article
- The PA and HA gene-mediated high viral load and intense innate immune response in the brain contribute to the high pathogenicity of H5N1 avian influenza virus in mallard ducks.Journal of virology · 2013Article
- Genetic analysis of the PB1-F2 gene of equine influenza virus.Virus genes · 2013Article
- Article
- The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks.Virology journal · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Despite reports that the PB1-F2 protein contributes to influenza virus pathogenicity in the mouse model, little is known about its significance in avian hosts. In our previous study, the A/Vietnam/1203/04 (H5N1) wild-type virus (wtVN1203) was more lethal to mallard ducks than a reverse genetics (rg)-derived VN1203. In search of potential viral factors responsible for this discrepancy, we found that synonymous mutations (SMs) had been inadvertently introduced into three genes of the rgVN1203 (rgVN1203/SM-3). Of 11 SMs in the PB1 gene, three resided in the PB1-F2 open reading frame, caused amino acid (aa) substitutions in the PB1-F2 protein, and reduced virus lethality in mallard ducks. The wtVN1203 and recombinant viruses with repairs to these three aa's (rgVN1203/R-PB1-F2) or with repairs to all 11 SMs (rgVN1203/R-PB1) were significantly more pathogenic than rgVN1203/SM-3. In cultured cells, repairing three mutations in PB1-F2 increased viral polymerase activity and expression levels of viral RNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.