ArticleRheumatology international2011
Detection of Chlamydophila pneumoniae in patients with arthritis: significance and diagnostic value.
Article in Rheumatology international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Clinical features and risk factors of liver injury in patients withFrontiers in cellular and infection microbiology · 2023Article
- Review
- No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis.The Journal of international medical research · 2019Article
- Subclinical Leishmania infection in patients with rheumatic diseases under biological drugs.Infection · 2018Article
- Detection of Shigella spp. nucleic acids in the synovial tissue of Tunisian rheumatoid arthritis patients and other forms of arthritis by quantitative real-time polymerase chain reaction.Rheumatology international · 2018Article
- Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research.Microorganisms · 2016Review
- Article
- Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection.Infectious agents and cancer · 2016Article
- Human blood monocytes support persistence, but not replication of the intracellular pathogen C. pneumoniae.BMC immunology · 2014Article
- High prevalence of hpv multiple genotypes in women with persistent chlamydia trachomatis infection.Infectious agents and cancer · 2014Article
- Downregulation of immunoglobulin-like transcript-4 (ILT4) in patients with psoriatic arthritis.PloS one · 2014Article
- Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report.Infectious agents and cancer · 2013Article
- The molecular basis for disease phenotype in chronic Chlamydia-induced arthritis.International journal of clinical rheumatology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to assess the potential clinical implications of Chlamydophila pneumoniae in patients with acute and chronic arthritic diseases and to investigate whether blood monocytes might reflect a concomitant synovial or persistent systemic infection. C. pneumoniae was investigated with advanced PCR and reverse transcriptase (RT) PCR techniques targeting different genes and combined with cell line cultures, in synovial fluid (SF) and peripheral blood mononuclear cell (PBMC) specimens collected from 28 patients with arthritis. Five out of twenty-eight patients (17.8%) were found to have C. pneumoniae DNA in either SF or PBMC specimens. Their diagnosis was reactive arthritis (ReA), S.A.P.H.O syndrome, psoriatic arthritis, undifferentiated oligoarthritis (UOA) and ankylosing spondylitis (AS). Specimens from patients with UOA and AS had also mRNA transcripts but those from AS yielded C. pneumoniae growth after co-culture. Moreover, C. pneumoniae DNA levels measured by Real-Time PCR (LightCycler) were higher in PBMC specimens compared to those found in SF at the end of antibiotic treatment. C. pneumoniae may have a role as triggering factor also in chronic arthritides including AS. The combined use of culture and molecular tools increases detection rates and improves the overall sensitivity, suggesting their potential use to detect C. pneumoniae. The different kinetics of bacterial DNA at both peripheral and synovial levels should be taken into consideration when monitoring and evaluating the effectiveness of antibiotic treatment.
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