Evidence map›Paper›PMID 20383277›Full record

ArticleJALA (Charlottesville, Va.)2010

Photonic Crystal Surfaces as a General Purpose Platform for Label-Free and Fluorescent Assays.

Brian T Cunningham

Abstract read
In one paragraph

Article in JALA (Charlottesville, Va.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Brian T CunninghamDepartment of Electrical and Computer Engineering Department of Bioengineering University of Illinois at Urbana-Champaign.

Funding

Photonic Crystal Surfaces for Label-Free Detection and Fluorescence AmplificationR01GM086382 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOLLERO, GERMAN A, CUNNINGHAM, BRIAN T. · 2009 to 2012
$1.7M
High-Throughput Small Molecule Screening Using Photonic Crystal Technology: AppliR01GM090220 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CUNNINGHAM, BRIAN T. · 2010 to 2013
$1.2M
Label-Free Screening Using Photonic Crystal Sensors for the Apoptotic PathwayR01CA118562 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CUNNINGHAM, BRIAN T. · 2006 to 2008
$603k
NCI NIH HHS R01 CA118562NIGMS NIH HHS R01 GM086382NIGMS NIH HHS R01 GM090220
6 · The paper itself

Abstract

Photonic crystal surfaces can be designed to provide a wide range of functions that are used to perform biochemical and cell-based assays. Detection of the optical resonant reflections from photonic crystal surfaces enables high sensitivity label-free biosensing, while the enhanced electromagnetic fields that occur at resonant wavelengths can be used to enhance the detection sensitivity of any surface-based fluorescence assay. Fabrication of photonic crystals from inexpensive plastic materials over large surface areas enables them to be incorporated into standard formats that include microplates, microarrays, and microfluidic channels. This report reviews the design of photonic crystal biosensors, their associated detection instrumentation, and biological applications. Applications including small molecule high throughput screening, cell membrane integrin activation, gene expression analysis, and protein biomarker detection are highlighted. Recent results in which photonic crystal surfaces are used for enhancing the detection of Surface-Enhanced Raman Spectroscopy, and the development of high resolution photonic crystal-based laser biosensors are also described.

Identifiers

PMID20383277
PMCPMC2850210

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.