Evidence map›Paper›PMID 20383269›Full record

ReviewExpert review of hematology2010

Optimizing reduced-intensity conditioning regimens for myeloproliferative neoplasms.

Aravind Ramakrishnan, Brenda M Sandmaier

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aravind RamakrishnanFred Hutchinson Cancer Research Center, University of Washington School of Medicine, 1100 Fairview Avenue N, D1-100, PO Box 19024, Seattle, WA 98109-1024, USA. aramakri@fhcrc.org
Brenda M Sandmaier
Fred Hutch Cancer Center · US

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STEPHANIE J LEE · 1985 to 2026
$128.4M
UNRELATED AND HLA-MISMATCHED RELATED DONOR TRANSPLANTSP01HL036444 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI RAWLINGS, DAVID J · 1986 to 2010
$25.9M
Generating iPS cells by reprogramming using small moleculesK08DK082783 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI RAMAKRISHNAN, ARAVIND · 2009 to 2013
$671k
NCI NIH HHS CA18029NCI NIH HHS P01 CA018029NHLBI NIH HHS HL36444NHLBI NIH HHS P01 HL036444NIDDK NIH HHS DK082783,NIDDK NIH HHS K08 DK082783
6 · The paper itself

Abstract

The myeloproliferative neoplasms (MPNs) are a group of clonal disorders that arise from a pluripotent hematopoietic stem cell and are characterized by excess cellular proliferation. These disorders tend to be chronic in nature and can terminate over time into a bone marrow failure syndrome characterized by marrow fibrosis or transform into a leukemic phase. MPNs are predominantly diseases of the elderly and this is one reason why until very recently the standard treatment was supportive care. The only curative modality for these disorders is allogeneic hematopoietic cell transplantation. The introduction of reduced-intensity conditioning regimens now allows this life-saving therapy to be offered to elderly patients who were previously considered ineligible for high-dose conditioning owing to age or comorbidity. In this review, we will summarize the current strategies and future directions regarding the use of reduced-intensity conditioning regimens in the treatment of MPNs.

Indexed as

Bone Marrow NeoplasmsHematopoietic Stem Cell TransplantationHumansMyeloproliferative DisordersTransplantation ConditioningTransplantation, Homologousbcr–ablgraft-versus-leukemiaJAK-2myeloproliferative neoplasmreduced-intensity conditioningstem cell transplant

Identifiers

PMID20383269
PMCPMC2850074
OpenAlexW2059580795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.