ArticleOncogene2010
Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma: an emerging cohesin role in tumor suppression.
Article in Oncogene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- MiR-223-3p in Cancer Development and Cancer Drug Resistance: Same Coin, Different Faces.International journal of molecular sciences · 2024Review
- PDS5B inhibits cell proliferation, migration, and invasion via upregulation of LATS1 in lung cancer cells.Cell death discovery · 2021Article
- PDS5A and PDS5B in Cohesin Function and Human Disease.International journal of molecular sciences · 2021Review
- miR-223 Regulates Cell Proliferation and Invasion via Targeting PDS5B in Pancreatic Cancer Cells.Molecular therapy. Nucleic acids · 2019Article
- Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing.Nucleic acids research · 2019Article
- Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions.Cancers · 2017Review
- Sparse conserved under-methylated CpGs are associated with high-order chromatin structure.Genome biology · 2017Article
- Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction.Nucleic acids research · 2016Article
- Pds5 regulators segregate cohesion and condensation pathways in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes.PloS one · 2014Article
- Article
- Overexpression of APRIN inhibits differentiation and proliferation and promotes apoptosis in P19 embryonal carcinoma cells.Molecular biology reports · 2013Article
- Diverse developmental disorders from the one ring: distinct molecular pathways underlie the cohesinopathies.Frontiers in genetics · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cohesins appear to have critical functions beyond mitotic cohesion. Our data on a cohesin-associated Pds5-paralog, APRIN, indicate a novel cohesin role in stem cell differentiation. APRIN/Pds5B is lost in many cancers and it is a putative tumor suppressor. Its mutations in the germ line, however, generate birth defects. We reasoned that as both cancer and birth defects share disrupted stem cell differentiation, the data suggest an APRIN/Pds5B cohesin function in stem cells. We used an embryonal carcinoma stem cell model and show here that (i) APRIN expression is precisely coordinated with stem cell differentiation; (ii) this coordination involves surface-contact and endocrine pathways; and (iii) APRIN/Pds5b coordination is critical in stem/progenitor exit decisions. APRIN knockdown disrupted Oct4, Nanog and SOX2 patterns, differentiation failed and the resulting immature proliferative cells did not progress beyond proneural progenitor phase. Furthermore, the phenotype-blocked progenitor exit (Mash-1(+)); failed E-cadherin exit (E-Cadh(low+)); incomplete N-cadherin transition (N-Cadh(low+)); retained proliferative capacity (c-myc(+)); irregular stemness (SOX2(late++)) and lost response to contact and hormonal cues-shares similarities with cancer-initiating cells. The data suggest novel APRIN/Pds5B-linked cohesin roles in stem/progenitor programs and a new mechanism in tumor suppression.
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